Results 71 to 80 of about 167,687,783 (193)

Public Health and Primary Care

open access: yesJournal of Primary Care & Community Health, 2011
Why are the goals of public health and primary care less politically popular and financially supported than those of curative medicine? A major part of the answer to this question lies in the fact that humans often worry wrongly by assessing risk poorly.
Rick Mayes PhD, Sean McKenna MD
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

How we stepped up to support others

open access: yeseLife
From diagnosis and disclosure to leading change, two neurodivergent researchers recount their experiences setting up peer support networks at their universities.
Christina Elliott, Patrick Brundell
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Autistic and abroad

open access: yeseLife
An AuDHD researcher recounts the highs and lows of relocating from the United States to Germany for his postdoc.
Andrew K Schulz
doaj   +1 more source

Distributed resource scheduling in smart grid with electric vehicle deployment using fireworks algorithm

open access: yesJournal of Modern Power Systems and Clean Energy, 2016
Global warming and climate change are two key probing issues in the present context. The electricity sector and transportation sector are two principle entities propelling both these issues.
K. Srikanth Reddy   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The experiences of employees participating in organisational corporate social responsibility initiatives

open access: yesSA Journal of Industrial Psychology, 2018
Orientation: This article is about the experiences of employees who actively participate in organisational corporate social responsibility (CSR) initiatives.
Gretha Cook, Dirk J. Geldenhuys
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

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