Results 111 to 120 of about 17,602 (258)

Mechanism‐informed machine learning for individualized tacrolimus dose adjustment in the early post‐kidney transplant period

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu   +4 more
wiley   +1 more source

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai   +9 more
wiley   +1 more source

Nonparametric Bayesian dictionary learning algorithm based on structural similarity

open access: yesTongxin xuebao, 2019
Though nonparametric Bayesian methods possesses significant superiority with respect to traditional comprehensive dictionary learning methods,there is room for improvement of this method as it needs more consideration over the structural similarity and ...
Daoguang DONG   +4 more
doaj   +2 more sources

Transfer Learning Approaches in Bioprocess Engineering: Opportunities and Challenges

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Transfer learning (TL) has recently emerged as a promising approach to overcoming one of the key limitations of bioprocess engineering: data scarcity. By leveraging knowledge from one bioprocess to another, TL allows existing models and data sets to be reused efficiently, accelerating process development, improving prediction accuracy, and ...
Daniel Barón Díaz   +3 more
wiley   +1 more source

The spread of non‐native species

open access: yesBiological Reviews, EarlyView.
ABSTRACT The global redistribution of species through human agency is one of the defining ecological signatures of the Anthropocene, with biological invasions reshaping biodiversity patterns, ecosystem processes and services, and species interactions globally.
Phillip J. Haubrock   +16 more
wiley   +1 more source

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