Results 91 to 100 of about 15,041 (261)
Advanced Science, EarlyView.This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi +13 more
wiley +1 more source
Methodological considerations in longitudinal morphometry of traumatic brain injury
Frontiers in Human Neuroscience, 2013 Traumatic brain injury (TBI) has recently been reconceptualized as a chronic, evolving disease process. This new view necessitates quantitative assessment of post-injury changes in brain structure that may allow more accurate monitoring and prediction of
Junghoon eKim +3 more
doaj +1 more source
Canonical correlation analysis for irregularly and sparsely observed functional data
Journal of Multivariate Analysis, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hyejin Shin, Seokho Lee
openaire +1 more source
Advanced Science, EarlyView.SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng +6 more
wiley +1 more source
Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning
Advanced Science, EarlyView.ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen +6 more
wiley +1 more source
Advanced Science, EarlyView.A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che +9 more
wiley +1 more source
Impact of Data Preprocessing on Integrative Matrix Factorization of Single Cell Data
Frontiers in Oncology, 2020 Integrative, single-cell analyses may provide unprecedented insights into cellular and spatial diversity of the tumor microenvironment. The sparsity, noise, and high dimensionality of these data present unique challenges.
Lauren L. Hsu +3 more
doaj +1 more source
Multi-omic modelling of inflammatory bowel disease with regularized canonical correlation analysis.
PLoS ONE, 2021 BackgroundPersonalized medicine requires finding relationships between variables that influence a patient's phenotype and predicting an outcome. Sparse generalized canonical correlation analysis identifies relationships between different groups of ...
Lluís Revilla +12 more
doaj +1 more source
A greedy approach to sparse canonical correlation analysis
, 2008 5 pages, 3 ...
Wiesel, Ami +2 more
openaire +2 more sources
Advanced Science, EarlyView.STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu +5 more
wiley +1 more source