Results 161 to 170 of about 513,547 (285)

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

open access: yesBMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu   +8 more
wiley   +1 more source

Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies. [PDF]

open access: yesNat Methods, 2016
Rahmani E   +10 more
europepmc   +1 more source

Fast Algorithms for Sparse PCA and Robust Sparse Estimation

open access: yes
We study fast algorithms for sparse-PCA certification. Given a positive semidefinite matrix $M$, the problem asks either to rule out a large $k$-sparse quadratic form or to return a high-value (relaxed) witness. The standard semidefinite relaxation provides such certificates, but existing general-purpose solvers require $Ω(d^4)$ time.
Iakovidis, Giannis, Pensia, Ankit
openaire   +2 more sources

Hot and cold deserts as eco‐evolutionary arenas for understanding plant resistance to multiple abiotic stressors

open access: yesBiological Reviews, EarlyView.
ABSTRACT During their long evolutionary history, land plants have evolved a range of adaptations to different abiotic stressors. These help explain present‐day diversity and distribution patterns, as well as the potential resilience of natural and agricultural systems to a changing climate. Most previous research has focused on adaptation to individual
Marc Fradera‐Soler   +6 more
wiley   +1 more source

CEO Managerial Ability and the Strategic Repetition of Climate Disclosures

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT This study examines whether CEO managerial ability shapes the repetition of firms' climate‐related disclosures in mandatory 10‐K filings. Climate reporting is highly judgment based and central to firms' broader climate‐risk management strategies, yet little is known about why some firms repeatedly use similar climate narratives and others ...
Javad Rajabalizadeh
wiley   +1 more source

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke   +12 more
wiley   +1 more source

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li   +27 more
wiley   +1 more source

Single‐Cell Reporter Dynamics During the First Two Rounds of Rhinovirus Plaque Growth

open access: yesCytometry Part A, EarlyView.
ABSTRACT When infection spreads from an initially infected cell through a cell monolayer, the resulting plaque records successive rounds of virus–cell interaction. Fluorescent reporter viruses permit this process to be followed at single‐cell resolution, but whether secondary infected cells retain detectable signatures associated with their plaque of ...
Rahul Ramachandran   +2 more
wiley   +1 more source

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