Results 191 to 200 of about 605,737 (255)

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Distinguishing examples while building concepts in hippocampal and artificial networks. [PDF]

Nat Commun
Kang L, Toyoizumi T.
europepmc   +1 more source

Quantitative Electron Beam‐Single Atom Interactions Enabled by Sub‐20‐pm Precision Targeting

Advanced Science, EarlyView.
Atomic lock‐on (ALO) is a rapid, low‐dose in situ technique in scanning transmission electron microscopy (STEM) that achieves sub‐20 picometer (pm) beam positioning. A sparse annular scan collects positional information while avoiding irradiation of the target site.
Kevin M. Roccapriore, Frances M. Ross, Julian Klein   +2 more
wiley   +1 more source

All-to-all reconfigurability with sparse and higher-order Ising machines. [PDF]

Nat Commun
Nikhar S, Kannan S, Aadit NA, Chowdhury S, Camsari KY.   +4 more
europepmc   +1 more source

BInD: Bond and Interaction‐Generating Diffusion Model for Multi‐Objective Structure‐Based Drug Design

Advanced Science, EarlyView.
Can a generative model design molecules that truly understand their targets? BInD, a diffusion‐based framework, co‐generates 3D molecules and their interactions with proteins by learning target‐specific interacting patterns. With knowledge‐based guidance and NCI‐driven optimization, BInD balances affinity, geometry, and drug‐likeness – pushing the ...
Joongwon Lee, Wonho Zhung, Jisu Seo, Woo Youn Kim   +3 more
wiley   +1 more source

qlty: handling large tensors in scientific imaging deep-learning workflows. [PDF]

Softw Impacts
Zwart PH.
europepmc   +1 more source

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

Advanced Science, EarlyView.
DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma   +8 more
wiley   +1 more source

Extended fiducial inference for individual treatment effects via deep neural networks. [PDF]

Stat Comput
Kim S, Liang F.
europepmc   +1 more source

AI‐Driven Defecation Analysis by Smart Healthcare Toilet: Exploring Biometric Patterns and Eu‐Tenesmus

Advanced Science, EarlyView.
A healthcare toilet system is introduced to passively measure defecation behavior. Real‐time data on stool dropping duration, thickness, and a newly defined “eu‐tenesmus” interval show correlations with stool form and gender differences. Results from 45 defecation events reveal a promising method for comprehensive defecation analysis.
Zhiquan Song, TaeHyung Kwon, Jeung Lee, Daeyoun D. Won, Brian J. Lee, Hyuk Soon Choi, Joseph C. Liao, Walter G. Park, Irene Sonu, Stephan Rogalla, Michael J. Rosen, David L. Hu, Jonathan Kuang Ziyang, Sunny Hei Wong, Bong Hyun Jun, Soh Kim, Seung‐min Park   +16 more
wiley   +1 more source

Network analysis of multivariate time series data in biological systems: methods and applications. [PDF]

Brief Bioinform
Mei H, Wang Z, Yang H, Li X, Xu Y.
europepmc   +1 more source