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Clinical profile and treatment of infantile spasms using vigabatrin and ACTH - a developing country perspective [PDF]

open access: yesBMC Pediatrics, 2010
Background Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment.
Ishaque Sidra   +3 more
doaj   +5 more sources

Infantile Spasms

open access: yesPediatric Neurology Briefs, 1988
Four infants with partial seizures evolving to infantile spasms were investigated using simultaneous EEG-video-telemetry recording in the Dept of Pediatrics, Nagoya University, Nagoya, and Division of Pediatric Neurology, Central Hospital, Aichi ...
J Gordon Millichap
doaj   +3 more sources

Current trends in the treatment of infantile spasms [PDF]

open access: yesNeuropsychiatric Disease and Treatment, 2009
Chang-Yong TsaoClinical Pediatrics and Neurology, The Ohio State University, College of Medicine, Columbus, Ohio, USAAbstract: Infantile spasms are an epilepsy syndrome with distinctive features, including age onset during infancy, characteristic ...
Chang-Yong Tsao
doaj   +3 more sources

Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms [PDF]

open access: yesNeuropsychiatric Disease and Treatment, 2010
Jason T Lerner1, Noriko Salamon2, Raman Sankar1,31Departments of Pediatrics, 2Radiological Sciences, 3Neurology, David Geffen School of Medicine, University of California Los Angeles and Mattel Children’s Hospital at UCLA, Los Angeles, CA ...
Jason T Lerner   +2 more
doaj   +5 more sources

Neurotransmission Sex Dichotomy in the Rat Hypothalamic Paraventricular Nucleus in Healthy and Infantile Spasm Model [PDF]

open access: yesCurrent Issues in Molecular Biology
We profiled the gene expressions in the hypothalamic paraventricular nuclei of 12 male and 12 female pups from a standard rat model of infantile spasms to determine the sex dichotomy of the neurotransmission genomic fabrics.
Dumitru Andrei Iacobas   +6 more
doaj   +2 more sources

Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG [PDF]

open access: yesEpilepsia Open
Objective Relapse of epileptic spasms after initial treatment of infantile epileptic spasms syndrome (IESS) is common. However, past studies of small cohorts have inconsistently linked relapse risk to etiology, treatment modality, and EEG features upon ...
Emmi Deckard   +7 more
doaj   +2 more sources

Infantile Spasms in Pediatric Down Syndrome: Potential Mechanisms Driving Therapeutic Considerations [PDF]

open access: yesChildren
Infantile spasms are common in Down Syndrome (DS), but the mechanisms by which DS predisposes to this devastating epilepsy syndrome are unclear.
Carl E. Stafstrom, Li-Rong Shao
doaj   +2 more sources

Prognosis of Infantile Spasms

open access: yesPediatric Neurology Briefs, 1993
The developmental, neurologic, and seizure outcome and prognostic factors of 57 cases of infantile spasms were evaluated in relation to etiology (cryptogenic 17 cases, symptomatic 40 cases) at the Hospital for Sick Children, Toronto, Canada.
J Gordon Millichap
doaj   +3 more sources

Asymmetric Infantile Spasms

open access: yesPediatric Neurology Briefs, 1995
Behavioral and EEG asymmetry and asynchrony of 8,680 infantile spasms were analysed in a review of 75 consecutive video-EEG recordings performed at UCLA Medical Center, Los Angeles from 1982 to 1992.
J Gordon Millichap
doaj   +4 more sources

Pathophysiology of Infantile Spasms

open access: yesPediatric Neurology Briefs, 1993
An age-specific endogenous-convulsant hypothesis implicating corticotropin-releasing hormone (CRH), an excitant neuropeptide suppressed by ACTH/steroids, is proposed for the pathophysiology of massive infantile spasms in a report from the University of ...
J Gordon Millichap
doaj   +3 more sources

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