Results 11 to 20 of about 142,677 (240)
EEG‐based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms
Epilepsia Open, 2023 Infantile epileptic spasms (IS) are epileptic seizures that are associated with increased risk for developmental impairments, adult epilepsies, and mortality.
Ioana Ma Samfira +5 more
semanticscholar +1 more source
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023 Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei +4 more
wiley +1 more source
Brain Magnetic Resonance Imaging Findings in Infantile Spasms
Neurology International, 2022 Background: Infantile spasms are an age-specific epileptic disorder. They occur in infancy and early childhood. They can be caused by multiple etiologies. Structural abnormalities represent an important cause of infantile spasms. Brain magnetic resonance
Osama Y. Muthaffar
doaj +1 more source
Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome
JCI Insight, 2022 Infantile spasms syndrome (IS) is a devastating early-onset epileptic encephalopathy associated with poor neurodevelopmental outcomes. When first-line treatment options, including adrenocorticotropic hormone and vigabatrin, are ineffective, the ketogenic
C. Mu +8 more
semanticscholar +1 more source
Etiologic Classification of 541 Infantile Spasms Cases: A Cohort Study
Frontiers in Pediatrics, 2022 Objective To explore the etiology of infantile spasms (IS) in a large Chinese cohort based on the United States National Infantile Spasms Consortium (NISC) classification.
P. Peng +9 more
semanticscholar +1 more source
EEG biomarkers for the diagnosis and treatment of infantile spasms
Frontiers in Neurology, 2022 Early diagnosis and treatment are critical for young children with infantile spasms (IS), as this maximizes the possibility of the best possible child-specific outcome.
Blanca Romero Milà +4 more
semanticscholar +1 more source
Inequities in Therapy for Infantile Spasms: A Call to Action
Annals of Neurology, 2022 The aim of this study was to determine whether selection of treatment for children with infantile spasms (IS) varies by race/ethnicity.
Fiona M. Baumer +22 more
semanticscholar +1 more source
Neurology, 2022 Background and Objectives Standard therapies (adrenocorticotropic hormone [ACTH], oral steroids, or vigabatrin) fail to control infantile spasms in almost half of children. Early identification of nonresponders could enable rapid initiation of sequential
Christopher J. Yuskaitis +14 more
semanticscholar +1 more source
Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants
Arquivos de Neuro-Psiquiatria, 2023 Background Infantile epileptic spasms syndrome (IESS) is a rare but severe condition affecting children early and is usually secondary to an identifiable brain disorder.
Letícia Pereira de Brito Sampaio +7 more
doaj +1 more source
Response to treatment and outcomes of infantile spasms in Down syndrome
Developmental Medicine & Child Neurology, 2022 To estimate the prevalence, and evaluate presentation, treatment response, treatment side effects, and long‐term seizure outcomes in all known cases of children with Down syndrome and infantile spasms on the island of Ireland.
Susan Harvey +9 more
semanticscholar +1 more source