Tuber Locations Associated with Infantile Spasms Map to a Common Brain Network
Annals of Neurology, 2021 Approximately 50% of patients with tuberous sclerosis complex develop infantile spasms, a sudden onset epilepsy syndrome associated with poor neurological outcomes.
A. Cohen +16 more
semanticscholar +1 more source
Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. [PDF]
, 2011 Infantile spasms is an epileptic encephalopathy of early infancy with specific clinical and electroencephalographic (EEG) features, limited treatment options, and a poor prognosis.
Arnason, Barry GW +10 more
core +2 more sources
A reliable interictal EEG grading scale for children with infantile spasms - The 2021 BASED score.
Epilepsy Research, 2021 OBJECTIVE To develop an improved interictal electroencephalogram (EEG) grading scale for children with infantile spasms founded on elements with adequate inter-rater reliability (IRR) to justify its further study for clinical and research purposes ...
J. Mytinger +4 more
semanticscholar +1 more source
Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms. [PDF]
, 1995 Infantile spasms respond to ACTH, and levels of the hormone in cerebrospinal fluid of untreated infants with this disorder were found to be lower than in age-matched controls. In this study we analyzed cerebrospinal fluid cortisol and ACTH using improved
Baram, TZ +4 more
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A pulse rapamycin therapy for infantile spasms and associated cognitive decline
Neurobiology of Disease, 2011 Infantile spasms are seizures manifesting within a spectrum of epileptic encephalopathies of infancy that often lead to cognitive impairment. Their current therapies, including adrenocorticotropic hormone (ACTH), high dose steroids, or vigabatrin, are ...
Emmanuel Raffo +4 more
doaj +1 more source
Response to sequential treatment with prednisolone and vigabatrin in infantile spasms
Journal of Paediatrics and Child Health, 2022 To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study
W. Dzau +6 more
semanticscholar +1 more source
Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort
Neurology, 2021 Objective To compare the effectiveness of initial treatment for infantile spasms. Methods The National Infantile Spasms Consortium prospectively followed up children with new-onset infantile spasms that began at age 2 to 24 months at 23 US centers (2012 ...
Z. Grinspan +20 more
semanticscholar +1 more source
Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options. [PDF]
, 2014 Seizures are clinically significant manifestations associated with 79%-90% of patients with tuberous sclerosis complex. Often occurring within the first year of life in the form of infantile spasms, seizures interfere with neuropsychiatric, social, and ...
Fallah, Aria, Wang, Shelly
core +2 more sources
Efficacy and tolerability of the Galanin Analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms [PDF]
, 2013 Infantile spasms are seizures manifesting in infantile epileptic encephalopathies that are associated with poor epilepsy and cognitive outcomes. The current therapies are not always effective or are associated with serious side effects.
Galanopoulou, A.S. +4 more
core +1 more source
Investigations in West Syndrome: Which, When and Why
Pediatric Neurology Briefs, 2015 Investigators from the National Infantile Spasms Consortium (NISC) in the USA studied the etiology of new-onset infantile spasms (IS) in 251 infants (mean age at onset, 7.1, range, 0.1-22.7 months).
Richard E Appleton
doaj +1 more source