Results 21 to 30 of about 133,799 (192)

Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort

Neurology, 2021
Objective To compare the effectiveness of initial treatment for infantile spasms. Methods The National Infantile Spasms Consortium prospectively followed up children with new-onset infantile spasms that began at age 2 to 24 months at 23 US centers (2012 ...
Z. Grinspan, K. Knupp, Anup D. Patel, Elissa G. Yozawitz, C. Wusthoff, E. Wirrell, I. Valencia, N. Singhal, D. Nordli, J. Mytinger, W. Mitchell, C. Keator, T. Loddenkemper, Shaun A. Hussain, C. Harini, W. Gaillard, I. Fernández, J. Coryell, C. Chu, A. Berg, R. Shellhaas   +20 more
semanticscholar   +1 more source

A model-based cost-effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome. [PDF]

Epilepsia Open
Abstract Objective Due to the conflicting evidence and expected regional therapeutic variations for cost‐effectiveness in children with infantile epileptic spasms syndrome (IESS), this study assessed treatment effectiveness, safety, Health‐Related Quality of Life (HRQoL), and performed a cost‐effectiveness analysis (CEA) for hormonal therapies in ...
Devi N, Madaan P, Bharti SK, Sahu JK, Bansal D.   +4 more
europepmc   +2 more sources

The link between brain acidosis, breathing and seizures: a novel mechanism of action for the ketogenic diet in a model of infantile spasms.

Brain Communications, 2021
Infantile spasms (IS) syndrome is a catastrophic, epileptic encephalopathy of infancy that is often refractory to current antiepileptic therapies. The ketogenic diet (KD) has emerged as an alternative treatment for patients with medically intractable ...
Anamika Choudhary, C. Mu, K. Barrett, Behshad Charkhand, Christine Williams-Dyjur, W. Marks, J. Shearer, J. Rho, Morris H. Scantlebury   +8 more
semanticscholar   +1 more source

EPILEPTIC SPASMS

Русский журнал детской неврологии, 2015
Epileptic spasms are epileptic seizures with sudden flexion/extension or of the mixed flexion and extension type, mainly involving the proximal and truncal muscles, that are normally longer than myoclonic seizures but shorter than tonic seizures, and ...
K. Yu. Mukhin, M. B. Mironov
doaj   +1 more source

Case Report: Rituximab Improved Epileptic Spasms and EEG Abnormalities in an Infant With West Syndrome and Anti-NMDAR Encephalitis Associated With APECED

Frontiers in Neurology, 2021
Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is a rare autosomal recessive disorder caused by a mutation in the autoimmune regulator gene.
Go Kawano, Takaoki Yokochi, Ryuta Nishikomori, Yoriko Watanabe, Keizo Ohbu, Yukitoshi Takahashi, Haruo Shintaku, Toyojiro Matsuishi, Toyojiro Matsuishi, Toyojiro Matsuishi   +9 more
doaj   +1 more source

Classifying etiology of infantile spasms syndrome in resource‐limited settings: A study from the South Asian region

Epilepsia Open, 2021
Etiological classification of infantile spasms syndrome (ISS) is important, considering the influence on prognosis based on the presence or absence of a known etiology.
J. Wanigasinghe, J. Sahu, Priyanka Madaan, K. Fatema, K. Linn, P. Chand, Prakash Poudel, Esmatullah Hamed, M. L. Mynak, S. Hassan   +9 more
semanticscholar   +1 more source

A pulse rapamycin therapy for infantile spasms and associated cognitive decline

Neurobiology of Disease, 2011
Infantile spasms are seizures manifesting within a spectrum of epileptic encephalopathies of infancy that often lead to cognitive impairment. Their current therapies, including adrenocorticotropic hormone (ACTH), high dose steroids, or vigabatrin, are ...
Emmanuel Raffo, Antonietta Coppola, Tomonori Ono, Stephen W. Briggs, Aristea S. Galanopoulou   +4 more
doaj   +1 more source

Historical Patterns of Diagnosis, Treatments, and Outcome of Epilepsy Associated With Tuberous Sclerosis Complex: Results From TOSCA Registry

Frontiers in Neurology, 2021
Background: Epilepsy is the most common neurological manifestation in individuals with tuberous sclerosis complex (TSC). However, real-world evidence on diagnosis and treatment patterns is limited.
Rima Nabbout, Elena Belousova, Mirjana P. Benedik, Tom Carter, Vincent Cottin, Paolo Curatolo, Maria Dahlin, Lisa D'Amato, Guillaume Beaure d'Augères, Petrus J. de Vries, José C. Ferreira, Martha Feucht, Carla Fladrowski, Carla Fladrowski, Christoph Hertzberg, Sergiusz Jozwiak, Sergiusz Jozwiak, John A. Lawson, Alfons Macaya, Ruben Marques, Ruben Marques, Finbar O'Callaghan, Jiong Qin, Matthias Sauter, Seema Shah, Yukitoshi Takahashi, Renaud Touraine, Sotiris Youroukos, Bernard Zonnenberg, Anna C. Jansen, J. Chris Kingswood   +30 more
doaj   +1 more source

Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions

Epilepsia, 2021
Infantile spasms may evolve into persistent epilepsies including Lennox‐Gastaut syndrome. We compared adult epilepsy outcomes in models of infantile spasms due to structural etiology (multiple‐hit model) or focal cortical inflammation and determined the ...
Ozlem Akman, Stephen W. Briggs, W. Mowrey, S. Moshé, A. Galanopoulou   +4 more
semanticscholar   +1 more source

Investigations in West Syndrome: Which, When and Why

Pediatric Neurology Briefs, 2015
Investigators from the National Infantile Spasms Consortium (NISC) in the USA studied the etiology of new-onset infantile spasms (IS) in 251 infants (mean age at onset, 7.1, range, 0.1-22.7 months).
Richard E Appleton
doaj   +1 more source