Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias
Neural Regeneration Research, 2019 Impaired axonal development and degeneration underlie debilitating neurodegenerative diseases including hereditary spastic paraplegia, a large group of inherited diseases.
Yongchao Mou, Xue-Jun Li
doaj +1 more source
Research on motor neuron diseases konzo and neurolathyrism : trends from 1990 to 2010 [PDF]
, 2012 Konzo (caused by consumption of improperly processed cassava, Manihot esculenta) and neurolathyrism (caused by prolonged overconsumption of grass pea, Lathyrus sativus) are two distinct non-infectious upper motor neurone diseases with identical clinical ...
Diasolua Ngudi, Delphin +3 more
core +2 more sources
Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]
, 2019 The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F. +4 more
core +1 more source
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
Effect of a new physiotherapy concept on bone mineral density, muscle force and gross motor function in children with bilateral cerebral palsy [PDF]
, 2010 Copyright @ 2010 The Authors.Objective: The purpose of this study was to determine the effect of a new physiotherapy concept on bone density, muscle force and motor function in bilateral spastic cerebral palsy children.
Nikopoulou-Smyrni, P +4 more
core
Measurement of the Angle of Plantar Flexion An Objective Way of Assessing Muscle Relaxation in Children with Spastic Cerebral Palsy [PDF]
Indian Journal of Physical Medicine & Rehabilitation, 2007 Infants and young children with spastic cerebral palsy (CP) do well with a single daily dose of diazepamgiven at bedtime, as the muscle relaxation decreases the spasticity and faciltates both passive and voluntarymovements.
Mathew A +4 more
doaj
Demographic and Clinical Characteristics of Patients with Cerebral Palsy
İstanbul Medical Journal, 2018 Introduction: The purpose of this study was to identify the demographic and clinical characteristics of patients with cerebral palsy (SP) who applied to the Physical Therapy and Rehabilitation Center and to increase the awareness of physicians and ...
Hamza Sucuoğlu
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Scoliosis Surgery in a Patient With Advanced Friedreich's Ataxia—It Is Not Too Late
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Friedreich's ataxia is a multisystem disorder with scoliosis being the most common non‐neurological manifestation. While scoliosis surgery is typically performed in adolescent, ambulatory patients, few data exist on surgical outcomes in patients with advanced disease.
Kathrin Reetz +20 more
wiley +1 more source
Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum. [PDF]
, 2007 Autosomal recessive hereditary spastic paraplegia (ARHSP) with thin corpus callosum (TCC) is a common and clinically distinct form of familial spastic paraplegia that is linked to the SPG11 locus on chromosome 15 in most affected families. We analyzed
AZZEDINE H +24 more
core
Travmatologiâ i Ortopediâ Rossii, 2016 Specific upper limb disorders accompanying spastic cerebral palsy substantially restrict self-care, writing abilities, hinder movements with external support aids and limit work capability.
A. A. Andreev +2 more
doaj +1 more source