Results 91 to 100 of about 62,561 (290)

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Spasticity [PDF]

, 2019
This chapter reviews the aetiology, pathophysiology, assessment, and treatment of spasticity in adults and children. We present an overview of the medical management options as well as the multidisciplinary input and rehabilitation required. Surgical interventions are then outlined with more sections on neurosurgery, plastic surgery, and orthopaedic ...
John Goodden, Catherine Hernon, Brian Scott   +2 more
openaire   +2 more sources

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Sequential Cryoneurolysis and Percutaneous Needle Tenotomy for Refractory Wrist Flexor Contracture: A Retrospective Case Series in Stroke and Spinal Cord Injury

Archives of Rehabilitation Research and Clinical Translation
Upper limb spasticity after stroke or spinal cord injury can lead to fixed wrist flexion contractures that limit hygiene, splinting, and functional positioning.
Paul Winston, MD, Hendrik Pepler, BSc, Sophie Alexander, BSc, Ibrahim Ali, MD, Mahdis Hashemi, MD   +4 more
doaj   +1 more source

Efficacy and safety of cannabinoids in the treatment of spasticity in multiple sclerosis: A systematic review of randomized clinical trials

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to evaluate the efficacy and safety of cannabinoids for the treatment of MS‐related spasticity. Methods Systematic searches were conducted in PubMed, EMBASE, and LILACS on 2 December 2025. Randomized controlled trials evaluating natural or synthetic cannabinoids for MS‐related spasticity were included.
Letícia Hamm‐Buiar, Daniela Gorski, Marcela Harumi Kagueiama, Astrid Wiens   +3 more
wiley   +1 more source

The efficacy of traditional Thai massage in decreasing spasticity in elderly stroke patients

, 2014
Thanitta Thanakiatpinyo,1 Supakij Suwannatrai,2 Ueamphon Suwannatrai,2 Phanitanong Khumkaew,2 Dokmai Wiwattamongkol,2 Manmas Vannabhum,2 Somluck Pianmanakit,1 Vilai Kuptniratsaikul1 1Department of Rehabilitation Medicine, 2Center of Applied Thai ...
Thanakiatpinyo T, Khumkaew P, Suwannatrai S, Kuptniratsaikul V, Vannabhum M, Suwannatrai U, Wiwattamongkol D, Pianmanakit S   +7 more
core  

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source

Predictive value of the pendulum test for assessing knee extensor spasticity

Journal of NeuroEngineering and Rehabilitation, 2018
Background The pendulum test is commonly used to quantify knee extensor spasticity, but it is currently unknown to what extent common pendulum test metrics can detect spasticity in patients with neurological injury or disease, and if the presence of ...
Alyssa Whelan, Andrew Sexton, Melony Jones, Colleen O’Connell, Chris A. McGibbon   +4 more
doaj   +1 more source

New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids

, 2010
Paul F SmithDepartment of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New ZealandAbstract: Cannabinoids such as Cannabis-based medicinal extracts (CBMEs) are increasingly being used in the treatment of ...
Paul F Smith
core  

Inclusion Complexations of Levamisole and Cocaine With Molecular Baskets. Fluorescence Displacement Assay for Detection of Cocaine and Its Adulterant Levamisole in Aqueous Media

Chemistry – A European Journal, EarlyView.
Levamisole is a common adulterant found in street‐distributed cocaine. Molecular baskets have been shown to form stable inclusion complexes with both substances. While levamisole inserts its benzene into the basket's cavity, cocaine utilizes its bicyclic ring for encapsulation.
Christopher T. Mortensen, Carson E. Ward, Nitesh Kumar, Logan Willemann, Ryan Lutz, Kailey Hughes, Zheng Zheng, Jovica D. Badjić   +7 more
wiley   +1 more source