Results 91 to 100 of about 3,145,207 (318)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Influence of Project-Based Learning (PJBL) Model on Spatial Thinking Ability in Class SMA PGRI 2 Palembang

open access: yes, 2019
One of the goals of learning geography is to give students the ability to think spatially. But based on observations in the field, it shows that students' spatial thinking skills have not shown maximum results.

core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Spatial clustering method for geographic data

open access: yes, 2002
In the process of visualizing quantitative spatial data, it is necessary to classify attribute values into some class divisions. In a previous paper, the author proposed a classification method for minimizing the loss of information contained in ...
Osaragi, Toshihiro
core  

How spatial omics approaches can be used to map the biological impacts of stress in psychiatric disorders: a perspective, overview and technical guide

open access: yesStress
Exposure to significant levels of stress and trauma throughout life is a leading risk factor for the development of major psychiatric disorders. Despite this, we do not have a comprehensive understanding of the mechanisms that explain how stress raises ...
Amber R. Curry   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Spatial variability of groundwater recharge - II. Factors affecting variability and taking account of it in estimating recharge

open access: yes, 2004
The accompanying paper provided evidence to suggest that spatial variability of groundwater recharge is ‘true’ variability. This paper attempts to determine the major causes of such variability even at small distances, if there appear to be a frequency ...
De Silva, RP
core  

Vertices 6—spatial@ucsb eNews [PDF]

open access: yes, 2013
This issue of Vertices highlights the transition in leadership of the Center for Spatial Studies from Michael Goodchild (geographer and founder of the Center) to Mary Hegarty (psychologist and scholar of spatial cognition.Special attention is given to ...
Center for Spatial Studies, UCSB
core  

Boolean and Spatial Analysis Using GIS to Determine Landfill Waste on Bunaken Island with an Environmental Health Approach

open access: yesJurnal Kesehatan Lingkungan
Introduction: Bunaken Island still lacks proper waste management infrastructure, resulting in the accumulation of garbage around residences and along the coastline.
Agus Bintara Birawida   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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