Results 131 to 140 of about 3,145,207 (318)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Spatial Science at QUT: Industry Report, March 2006
, 2006 New course coordinator (super course coordinator) for all Bachelor of Urban Development offerings, including spatial science, construction management, property economics, quantity surveying and urban and regional ...
Webb, Robert M.
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Journal of Education, Health and Sport, 2017 Actuality. The spatial organization of the bodies biolanceres is the most important concept consequent with the orientation of the body and its motor action in space.
Vitaliy Kashuba +2 more
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Vertices 5—spatial@ucsb eNews [PDF]
, 2011 Two articles are featured. The first, by Wenwen Li, describes some of the mapping issues associated with a UC-Muliti-campus Research Program and Initiatives (MRPI) project about the metropolitan economy of the Los Angeles region.
Center for Spatial Studies, UCSB
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Jurnal Kesehatan LingkunganIntroduction: Mycobacterium tuberculosis bacteria can cause tuberculosis disease. In 2022, East Java Province reported 8,398 cases of child tuberculosis with a discovery coverage of 105.6%.
Ambarsih Prameswari +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
An integrated framework to assess spatial and related implications of biomass delivery chains
, 2011 The overall objective of the ME4 research project was to develop an integrated framework to assess and analyse the spatial implications and related opportunities and consequences of an increased implementation of biomass delivery chains for energy ...
Sanders, J.P.M. +3 more
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