Results 141 to 150 of about 3,145,207 (318)
, 2008 This brochure documents the interdisciplinary breadth of the spatial perspective for research and teaching. Although this argument focuses on UC Santa Barbara, it could be easily documented for nearly all institutions of highter ...
Center for Spatial Studies, UCSB
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Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Vertices 4—spatial@ucsb eNews [PDF]
, 2010 Vertices 4 reviews tools for map making in the arts and humanities at UCSB, describes summer workshops in advanced spatial analysis, and features an article by Nathaniel Royal on his experiences in documenting Guinea worm disease proceses in ...
Center for Spatial Studies, UCSB
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Spatial behaviour and the socio-spatial recognition
, 2014 The paper explores the relation between the real and the mental space of the inhabitants. The understanding of the interaction between the inhabitants and their houses relies upon the direct observation of the practices of the users and the interpretation of their spatial behaviours shown by the routes they choose in everyday activities.
Regaya, Imen +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Vertices 2—spatial@ucsb eNews [PDF]
, 2009 This issue of Vertices features plans for developing a new inter-disciplinary undergraduate minor in spatial studies at UCSB.
Center for Spatial Studies, UCSB
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Spatial Neglect: A Window into Spatial Cognition and Beyond
Japanese Journal of Cognitive Neuroscience, 2009 Unilateral cerebral lesions may bring about a multifaceted pattern of impairment of spatial cognition, termed “unilateral spatial neglect”. The deficit is more frequent and severe after lesions involving the right cerebral hemisphere, and concerns the left side of space, contralateral to the side of the lesion contralesional.
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Vertices 7—spatial@ucsb eNews [PDF]
, 2013 This issue introduces Werner Kuhn, who joins the Center as its new director in November 2013. Following six years since the founding of the Center, this issue of Vertices offers reflections on gardening in retirement (Mike Goodchild), and updates on the ...
Center for Spatial Studies, UCSB
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