Results 191 to 200 of about 1,688,232 (308)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Neoadjuvant Therapy-Induced Remodeling in Pancreatic Ductal Adenocarcinoma: Multimodal Spatial Analysis and Prognosis. [PDF]

Cancer Sci
Zhang X, Lan R, Li D, Liu Y, Kalyan S, Iqbal M, Liu N, Zhang J, Hanna I, Gupta M, Zhao CL, Liu W, Melamed J, Shusterman M, Widmer J, Allendorf J, Liu YZ.   +16 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs. [PDF]

Nat Struct Mol Biol
Mota-Gómez I, Rodríguez JA, Dupont S, Hurtado A, Cadenas V, Zuber L, Maceda I, Lao O, Jedamzick J, Kühn R, Lacadie S, García-Moreno SA, Torres M, Real FM, Acemel RD, Capel B, Marti-Renom MA, Lupiáñez DG.   +17 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Spatial analysis of malaria incidence and environmental determinants in Hadiya Zone, Ethiopia. [PDF]

Sci Rep
Abdo SS.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Prevalence and risk factors of child morbidity with spatial analysis among under five children in Bangladesh. [PDF]

Sci Rep
Rashid MM, Rahman M, Miah MS, Islam MS, Roy TK, Bhuiyan MJ.   +5 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Spatial analysis of mortality due to congenital syphilis in Brazil from 2008 to 2022. [PDF]

PLoS One
Pinheiro YT, da Silva RAR, Costa KTDS, Oliveira AGRDC, da Costa JD, Marinho CDSR, de Freitas Filho JA, Rocha LKA, Moreira VS, Monteiro RCQ, Holanda JRR.   +10 more
europepmc   +1 more source