Results 71 to 80 of about 617,742 (295)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The mechanisms of spatial and temporal earthquake clustering

, 2009
The number of earthquakes as a function of magnitude decays as a power law. This trend is usually justified using spring-block models, where slips with the appropriate global statistics have been numerically observed.
A. B. Kolton, Baiesi, Baiesi, Bak, Bak, Baumberger, Ben-Zion, Ben-Zion, Bonamy, Braun, Burridge, Carlson, Chauve, Corral, Corral, Cugliandolo, Cule, Das, Dieterich, Dieterich, Dieterich, Dieterich, Durin, E. A. Jagla, Felzer, Fisher, Frohlich, Gomberg, Govaert, Gutenberg, Hainzl, Hainzl, Helmstetter, Helmstetter, Hergarten, Ho Huu, Ito, Jagla, Johnson, Lacombe, Le Doussal, Le Doussal, Lemerle, Marcellini, Marone, Marone, Marone, Mikumo, Moretti, Moulinet, Narayan, Narteau, Niemeijer, Nur, Olami, Omori, Perfettini, Persson, Repain, Rosso, Rosso, Rosso, Ruina, Scholz, Scholz, Scholz, Shaw, Utsu, Utsu, Wiemer, Zaliapin, Zapperi, Ziv, Ziv, Zöller   +74 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Metropol Kentlerde Hemşehri Kümelenmesi Üzerine Mekânsal Bir Analiz Çalışması: Bursa’daki Erzurumlular Örneği

Doğu Coğrafya Dergisi
Nedeni, oluşum süreci ve sonuçları göç eden kişi, aile veya topluluğa göre değişen göç, tek bir olay üzerinden incelenebileceği gibi genel değendirmelerle de ele alınabilir.
İbrahim Eşim, Nilgün Zaman
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Clustering similar spatial patterns

, 2021
TLTR: Clustering similar spatial patterns requires one or more raster datasets for the same area. Input data is divided into many sub-areas, and spatial signatures are derived for each sub-area. Next, distances between signatures for each sub-area are calculated and stored in a distance matrix.
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comparison of Supervised Learning Methods for Spatial User Clustering in Downlink NOMA

Buletin Pos dan Telekomunikasi: Media Komunikasi Ilmiah
The performance of Power Domain Non-Orthogonal Multiple Access (PD-NOMA) is affected by the performance of Successive Interference Cancellation (SIC) in decoding user data.
Hurianti Vidyaningtyas, Iskandar, Hendrawan, Aloysius Adya Pramudita   +3 more
doaj   +1 more source

Image segmentation using fuzzy clustering incorporating spatial information [PDF]

, 2004
Effective image segmentation cannot be achieved for a fuzzy clustering algorithm based on using only pixel intensity, pixel locations or a combination of the two.
Ali, Ameer, Dooley, Laurence S., Karmakar, Gour C.   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source