Results 31 to 40 of about 7,123,257 (262)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

L’officina cosmica. Biosfera, organizzazione, ecologia nel pensiero pre-cibernetico russo

open access: yesPhilosophy Kitchen, 2023
The biosphere is a great machinery of mutual transmutations, resulting in growing extension and heterogeneity. Organic and inorganic matter is caught in progressive cycles of transformation of cosmic radiation into active energy.
Francesco Vitali Rosati
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Sensitivity to Oxygen in Microbial Electrochemical Systems Biofilms

open access: yesiScience, 2019
Summary: The formation and bioelectric performance of anode biofilms in microbial electrochemical systems (MESs) are sensitive to oxygen. Investigating the temporal-spatial structure of anode biofilms will help elucidate the interfaces between oxygen and
Jiawei Yang   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Ways in which coherence is confirmation conducive [PDF]

open access: yes, 2006
Recent works in epistemology show that the claim that coherence is truth conducive – in the sense that, given suitable ceteris paribus conditions, more coherent sets of statements are always more probable – is dubious and possibly false.
Moretti L, Luca Moretti, Moretti, Luca
core   +1 more source

Full polarization and high coherence control of thermal emissions via saddle-band dispersion engineering

open access: yesNature Communications
Photonic engineering in metasurfaces has enabled unprecedented control over thermal emissions in recent years. Here, we present a design strategy that achieves full and simultaneous control over both polarization and coherence of thermal emission across ...
Kaili Sun   +7 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Quantum entanglement and spin control in silicon nanocrystal. [PDF]

open access: yesPLoS ONE, 2012
Selective coherence control and electrically mediated exchange coupling of single electron spin between triplet and singlet states using numerically derived optimal control of proton pulses is demonstrated.
Vesna Berec
doaj   +1 more source

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