Results 101 to 110 of about 3,413,400 (323)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Compatible Spatial Discretizations for Partial Differential Equations [PDF]

, 2004
From May 11--15, 2004, the Institute for Mathematics and its Applications held a hot topics workshop on Compatible Spatial Discretizations for Partial Differential Equations. The numerical solution of partial differential equations (PDE) is a fundamental task in science and engineering.
openaire   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Spatial Justice and Accessibility: Optimizing Sports Facility Allocation in Tehran

Land
The optimal allocation of sport facilities is crucial for urban management, as it enhances public health and improves citizens’ quality of life. This study proposed a novel decision-making approach for optimizing the allocation of sports facilities in a ...
Rohollah Asgari Gandomani, Amir Rahimi, Leila Shahbazpour, Jamal Jokar Arsanjani   +3 more
doaj   +1 more source

Paraxial light in a Cole-Cole nonlocal medium: integrable regimes and singularities

, 2005
Nonlocal nonlinear Schroedinger-type equation is derived as a model to describe paraxial light propagation in nonlinear media with different `degrees' of nonlocality.
Konopelchenko, Boris, Moro, Antonio
core   +2 more sources

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Spatial stimulus-response compatibility and affordance effects are not ruled by the same mechanisms

Frontiers in Human Neuroscience, 2015
Stimulus position is coded even if it is task-irrelevant, leading to faster response times when the stimulus and the response locations are compatible (spatial Stimulus-Response Compatibility – spatial SRC).
Marianna eAmbrosecchia, Barbara F.M. Marino, Luiz G. Gawryszewski, Lucia eRiggio   +3 more
doaj   +1 more source

Fine-Grained Object Recognition and Zero-Shot Learning in Remote Sensing Imagery

, 2017
Fine-grained object recognition that aims to identify the type of an object among a large number of subcategories is an emerging application with the increasing resolution that exposes new details in image data.
Aksoy, Selim, Cinbis, Ramazan Gokberk, Sumbul, Gencer   +2 more
core   +2 more sources