Results 111 to 120 of about 4,092,369 (293)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Complexity analysis of spontaneous brain activity: effects of depression and antidepressant treatment [PDF]

, 2011
Magnetoencephalography (MEG) allows the real-time recording of neural activity and oscillatory activity in distributed neural networks. We applied a non-linear complexity analysis to resting-state neural activity as measured using whole-head MEG ...
Tomás Ortiz, Pilar Zuluaga, Javier Escudero, Alberto Fernández, María Andreina Méndez, Carlos Gómez, Roberto Hornero, Alfonso Rodríguez-Palancas, Escudero, Javier; id_orcid, Fernandez, Alberto, Méndez, María Andreína, Andreina Mendez, Maria, Gomez, Carlos, Rodriguez Palancas, Alfonso, Fernandez Perez, Alberto, Hornero, Roberto, Ortiz, Tomas, Rodriguez-Palancas, Alfonso, Zuluaga Arias, María del Pilar, Escudero, Javier, Zuluaga, Pilar, Fernández Lucas, Alberto Amable   +21 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Adaptive Governance and sub-national Climate Change Policy: A comparative analysis of Khyber Pukhtunkhawa and Punjab Provinces in Pakistan

, 2019
This study explores the adaptive governance and effective implementation of climate policies at the subnational level in a developing country context. We focused on Pakistan as our central case as it is considered one of the most vulnerable countries to ...
H. Ali, Saleem, Mumtaz, Muhammad
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A low-complexity detection scheme for differential spatial modulation

, 2015
Differential spatial modulation (DSM), which does not require the channel state information at the receiver, is an attractive alternative to its coherent counterpart.
Yang, Ping, Xiang, Wei, Li, Shaoqian, Xiao, Yue, Li, Shaoqian, Xiao, Lixia, Lei, Xia, Fan, Shiwen   +7 more
core   +1 more source

Does scale-dependent feedback explain spatial complexity in salt-marsh ecosystems? [PDF]

, 2008
Complexity theory highlights scale-dependent feedback mechanisms as an explanation for regular spatial patterning in ecosystems. To what extent scale-dependent feedback clarifies spatial structure in more complex, non-regular systems remains unexplored ...
Tjeerd J. Bouma, Van Wesenbeeck, B.K., Bregje K. van Wesenbeeck, Peter M. J. Herman, Johan Van De Koppel, Herman, P.M.J., Wesenbeeck, B.K. Van, Van de Koppel, J., Bouma, T.J., Koppel, J. van de   +9 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Complexity, economics, and innovation policy: How two kinds of science lead to two kinds of economics and two kinds of policy

, 2017
One interpretation of complexity science is that it distinguishes two types of science—an equilibrium science of forces, as begun by Newton, and a complexity science of rules, as exemplified by Wolfram (2002).
Potts, Jason, Jason Potts
core   +1 more source