Results 101 to 110 of about 4,738,354 (293)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Teaching complexity in public administration across the globe: an overview [PDF]

open access: yes, 2018
As the contributions in this special issue show, there are ample examples of teaching programs at the nexus of complexity and public administration and its sub-fields.
Gerrits, Lasse   +3 more
core   +1 more source

Low-complexity optimal MPSK detection for spatial modulation

open access: yesTongxin xuebao, 2015
The low-complexity optimal SM detection algorithm for MQAM signal detection had been proposed,but no similar method was found for MPSK signal.The problem of low-complexity detection for MPSK signal was considered in SM systems.Utilizing 2-D vector ...
Hong-zhi MEN, Ming-lu JIN
doaj   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

ON POTENTIALIZED PARTIAL FINITE DIFFERENCE EQUATIONS: ANALYZING THE COMPLEXITY OF KNOWLEDGE-BASED SPATIAL ECONOMIC DEVELOPMENTS [PDF]

open access: yes
Knowledge-based regional and urban studies are plentiful; some systematics might be in order at this junction, so first the different links between economic production units in geographical space have to be clearly defined.
Bernard COUTROT   +3 more
core  

Teaching Complexity: The Limits of Evidence and the ‘Prospective’ Case Study [PDF]

open access: yes, 2018
Policy practitioner–students in a Master of Public Policy programme in New Zealand describe many problems and processes in their work environments as ‘complex’.
Wolf, Amanda, Amanda Wolf
core   +1 more source

Quantifying the Complexity of Rough Surfaces Using Multiscale Entropy: The Critical Role of Binning in Controlling Amplitude Effects

open access: yesMathematics
A salient feature of modern material surfaces used in cutting-edge technologies is their structural and spatial complexity, which endows them with novel properties and multifunctionality.
Alex Kondi   +3 more
doaj   +1 more source

Spatial Complexity of a Predator-Prey Model with Holling-Type Response

open access: yesAbstract and Applied Analysis, 2014
We focus on a spatially extended Holling-type IV predator-prey model that contains some important factors, such as noise (random fluctuations), external periodic forcing, and diffusion processes.
Lei Zhang, Zhibin Li
doaj   +1 more source

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