Results 81 to 90 of about 4,738,354 (293)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Public Administration and Complexity – or how to teach things we can’t predict? [PDF]

, 2018
Introduction to the special issue ‘Teaching ...
Mary Lee Rhodes, Eppel, Elizabeth Anne, Rhodes, Mary Lee, Elizabeth Anne Eppel   +3 more
core   +1 more source

Structural Change in Romanian Land Use and Land Cover (1990–2018): A Multi-Index Analysis Integrating Kolmogorov Complexity, Fractal Analysis, and GLCM Texture Measures

Geomatics
Monitoring land use and land cover (LULC) transformations is essential for understanding socio-ecological dynamics. This study assesses structural shifts in Romania’s landscapes between 1990 and 2018 by integrating algorithmic complexity, fractal ...
Ion Andronache, Ana-Maria Ciobotaru
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Teaching Complexity by means of Problem-Based Learning: Potential, Practice, and Pitfalls [PDF]

, 2018
This paper examines the use of Problem-Based Learning (PBL) in teaching the complexity sciences to students in public administration, policy, and management.
Gerrits, Lasse, Wirtz, Martin, Martin Wirtz, Lasse Gerrits   +3 more
core   +1 more source

Symmetry and Correspondence of Algorithmic Complexity over Geometric, Spatial and Topological Representations

Entropy, 2018
We introduce a definition of algorithmic symmetry in the context of geometric and spatial complexity able to capture mathematical aspects of different objects using as a case study polyominoes and polyhedral graphs.
Hector Zenil, Narsis A. Kiani, Jesper Tegnér   +2 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A Complexity-Theoretic Perspective on Innovation Policy [PDF]

, 2017
It is argued that innovation policy based on notions of market failure or system failure is too limited in the context of current societal challenges. I propose a third, complexity-theoretic approach.
Frenken, K., Frenken, Koen, Koen Frenken, Innovation Studies, Dynamics of Innovation Systems   +4 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Low complexity detection algorithm applied to spatial modulation system

Dianzi Jishu Yingyong, 2019
The paper proposes a low-complexity detection algorithm for spatial modulation. The proposed algorithm reduces the total complexity by reordering the receiving antennas. The algorithm combines the existing A-Star algorithm to layer and sort the receiving
Wang Huahua, Chen Dongfeng, Ma Chang, Kang Cheng   +3 more
doaj   +1 more source