Results 71 to 80 of about 326,953 (255)

On a Spatial Generalization of the Complex $\Pi$-Operator

Zeitschrift für Analysis und ihre Anwendungen, 1996
The \Pi -operator plays a mayor role in complex analysis, especially in the theory of generalized analytic functions in the sense of Vekua. The present paper deals with a hyper-complex generalization of the complex
Gürlebeck, K., Kähler, U.
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Modelling H5N1 in Bangladesh across spatial scales: Model complexity and zoonotic transmission risk

Epidemics, 2017
Highly pathogenic avian influenza H5N1 remains a persistent public health threat, capable of causing infection in humans with a high mortality rate while simultaneously negatively impacting the livestock industry.
Edward M. Hill, Thomas House, Madhur S. Dhingra, Wantanee Kalpravidh, Subhash Morzaria, Muzaffar G. Osmani, Mat Yamage, Xiangming Xiao, Marius Gilbert, Michael J. Tildesley   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

GEO-MATHEMATICAL MODELLING OF SPATIAL-ECOLOGICAL COMPLEX SYSTEMS: AN EVALUATION

Geography, Environment, Sustainability, 2010
Assessing the complexity of landscapes is one of the top research priorities for Physical Geography and Ecology. This paper aims at a methodological evaluation of the discrete and analytical mathematical models hitherto available for quantitative ...
Fivos Papadimitriou
doaj   +1 more source

Signal detection by complex spatial filtering [PDF]

IEEE Transactions on Information Theory, 1964
Summary: In the past, spatial filtering in coherent optical systems has been limited by the inability to realize practically a general complex filter. This paper describes a technique for realizing such a filter, and gives an application of spatial filtering to the problem of detecting isolated signals in a variety of noise backgrounds.
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Quantifying the Complexity of Rough Surfaces Using Multiscale Entropy: The Critical Role of Binning in Controlling Amplitude Effects

Mathematics
A salient feature of modern material surfaces used in cutting-edge technologies is their structural and spatial complexity, which endows them with novel properties and multifunctionality.
Alex Kondi, Vassilios Constantoudis, Panagiotis Sarkiris, Evangelos Gogolides   +3 more
doaj   +1 more source

The IH-complex of Spatial Trivalent Graphs

Tokyo Journal of Mathematics, 2010
The authors define the IH-complex on the set of spatial trivalent graphs as follows: The vertices of the complex are isotopy classes of spatial trivalent graphs, and two vertices are connected by an edge if one graph can be obtained from another by an IH-move.
ISHII, Atsushi, KISHIMOTO, Kengo
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source