Results 71 to 80 of about 4,738,354 (293)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Intersections in delta development; analyzing actors for complexity- sensitive spatial concepts [PDF]

, 2013
Delta areas can be considered complex adaptive socio-ecological systems. The Dutch Southwest delta, facing serious flood risks, vulnerability to ecological decline, and various challenging issues of agriculture, industry, harbor development and energy ...
Pel, Bonno, Pel, B (Bonno), van Popering - Verkerk, Jitske, van Popering-Verkerk, Jitske, Edelenbos, Jurian, van Buuren, Arwin, van Buuren, Arwin; id_orcid   +6 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Calibration for Improving the Medium-Range Soil Forecast over Central Tibet: Effects of Objective Metrics’ Diversity

Atmosphere
The high spatial complexities of soil temperature modeling over semiarid land have challenged the calibration–forecast framework, whose composited objective lacks comprehensive evaluation.
Yakai Guo, Changliang Shao, Guanjun Niu, Dongmei Xu, Yong Gao, Baojun Yuan   +5 more
doaj   +1 more source

The Complexity of Reasoning about Spatial Congruence

Journal of Artificial Intelligence Research, 1999
In the recent literature of Artificial Intelligence, an intensive research effort has been spent, for various algebras of qualitative relations used in the representation of temporal and spatial knowledge, on the problem of classifying the computational complexity of reasoning problems for subsets of algebras.
openaire   +4 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Energy-Aware Spatial and Temporal Resolution Selection for Per-Title Encoding

IEEE Access
Video streaming has become an integral part of our digital lives, driving the need for efficient video delivery. With the growing demand for seamless video delivery, adaptive video streaming has emerged as a solution to support users with varying device ...
Mohammad Ghasempour, Hadi Amirpour, Christian Timmerer   +2 more
doaj   +1 more source

Spatiotemporal Permutation Entropy as a Measure for Complexity of Cardiac Arrhythmia

Frontiers in Physics, 2018
Permutation entropy (PE) is a robust quantity for measuring the complexity of time series. In the cardiac community it is predominantly used in the context of electrocardiogram (ECG) signal analysis for diagnoses and predictions with a major application ...
Alexander Schlemmer, Alexander Schlemmer, Sebastian Berg, Sebastian Berg, Thomas Lilienkamp, Thomas Lilienkamp, Stefan Luther, Stefan Luther, Stefan Luther, Stefan Luther, Stefan Luther, Ulrich Parlitz, Ulrich Parlitz, Ulrich Parlitz   +13 more
doaj   +1 more source