Results 61 to 70 of about 4,092,369 (293)

Adaptive multi-criteria ecotopes: a memory-embedded cellular automata framework

Open Geosciences
Cellular automata (CA) are common instruments for simulating spatial dynamics in geography, ecology, and urban science. Most implementations, however, rely on fixed transition rules or static suitability surfaces that remain invariant across simulation ...
Vaz Eric
doaj   +1 more source

Teaching Complexity: The Limits of Evidence and the ‘Prospective’ Case Study [PDF]

, 2018
Policy practitioner–students in a Master of Public Policy programme in New Zealand describe many problems and processes in their work environments as ‘complex’.
Wolf, Amanda, Amanda Wolf
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Building Resilience in Trans-boundary Social-Ecological Systems: Adaptive Governance in the Lake Champlain Richelieu River Basin

, 2019
Addressing the management of water bodies that cross political, cultural, and ecological boundaries entails working with a level of complexity that requires creative, adaptive management strategies that build resilience throughout the system and allow ...
Spett, Emma J
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Quantifying Spatial Complexity and Signage Distribution in Large-Scale Hospital Wayfinding: A Space Syntax Analysis of a Medical Center

ISPRS International Journal of Geo-Information
Wayfinding difficulty in large-scale hospitals constitutes a form of healthcare accessibility barrier, affecting patient experience, appointment adherence, and operational efficiency—particularly for elderly, first-time, and cognitively burdened users ...
Keunhye Lee, Taebean Lim, Kilho Lee, Chong-Ku Park   +3 more
doaj   +1 more source

Spatial embedding and the structure of complex networks [PDF]

Complexity, 2010
AbstractWe review and discuss the structural consequences of embedding a random network within a metric space such that nodes distributed in this space tend to be connected to those nearby. We find that where the spatial distribution of nodes is maximally symmetrical some of the structural properties of the resulting networks are similar to those of ...
Seth Bullock, Lionel C. Barnett, Ezequiel A. Di Paolo   +2 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source