Results 61 to 70 of about 4,738,354 (293)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Query processing of spatial objects: Complexity versus Redundancy [PDF]
, 1993 The management of complex spatial objects in applications, such as geography and cartography, imposes stringent new requirements on spatial database systems, in particular on efficient query processing. As shown before, the performance of spatial query
Kriegel, Hans-Peter +3 more
core +1 more source
Spatial embedding and the structure of complex networks [PDF]
Complexity, 2010 AbstractWe review and discuss the structural consequences of embedding a random network within a metric space such that nodes distributed in this space tend to be connected to those nearby. We find that where the spatial distribution of nodes is maximally symmetrical some of the structural properties of the resulting networks are similar to those of ...
Seth Bullock +2 more
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A low-complexity detection scheme for differential spatial modulation
, 2015 Differential spatial modulation (DSM), which does not require the channel state information at the receiver, is an attractive alternative to its coherent counterpart.
Yang, Ping +6 more
core +1 more source
Children's construction task performance and spatial ability: controlling task complexity and predicting mathematics performance. [PDF]
, 2014 This paper presents a methodology to control construction task complexity and examined the relationships between construction performance and spatial and mathematical abilities in children.
Richardson, Miles +5 more
core +1 more source
Fabrication of Spatially Confined Complex Oxides [PDF]
Journal of Visualized Experiments, 2013 Complex materials such as high Tc superconductors, multiferroics, and colossal magnetoresistors have electronic and magnetic properties that arise from the inherent strong electron correlations that reside within them. These materials can also possess electronic phase separation in which regions of vastly different resistive and magnetic behavior can ...
Hangwen, Guo, Thomas Z, Ward
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Reflections on Entropy, Complexity and Spatial Dynamics: The Rebirth of Theory?
, 2021 This Handbook explores new and old theoretical, methodological, and empirical insights and perspectives on entropy, complexity, and spatial dynamics. A central and cross-cutting theme of the Handbook is the role of entropy in complex, dynamic spatial ...
L. A. Schintler +3 more
core +1 more source
Spatial Embedding and Complexity: The Small-World is Not Enough
, 2007 The “order for free” exhibited by some classes of system has been exploited by natural selection in order to build systems capable of exhibiting complex behaviour. Here we explore the impact of one ordering constraint, spatial embedding, on the dynamical
Bullock, Seth, Buckley, Christopher L
core +1 more source