Results 31 to 40 of about 226,967 (265)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Genotype Syntactic Study of Vernacular Houses in Biskra City
Iconarp International Journal of Architecture and Planning, 2021 Purpose This paper provides an analysis of the vernacular houses of the city of Biskra, in the north-eastern Algerian Sahara. The aim is to examine the underlying genotype of the spatial configuration of the city's vernacular house plans and to ...
Rihane Barkat +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Estimating the Spatial Reuse with Configuration Models
CoRR, 2014 We propose a new methodology to estimate the spatial reuse of CSMA-like scheduling. Instead of focusing on spatial configurations of users, we model the interferences between users as a random graph. Using configuration models for random graphs, we show how the properties of the medium access mechanism are captured by some deterministic differential ...
Paola Bermolen +3 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Analysis of the Spatial Configuration in Cinema on a Human Scale: ‘The Secret World of Arrietty’
EtkileşimSpace design is a research field with a broad framework that interacts with different disciplines. Scale, one of the most important components of this field, is used to increase the cinematic effect in the configuration of f ilm spaces.
Zeynep Fatma Niğdeli +1 more
doaj +1 more source
Built Heritage, 2023 The Daming Temple, built during 457–464 C.E., is one of the developing ancient temple heritage spaces located in Yangzhou city, P. R. China. Over the past 60 years, variation in visitors’ spatial perception along the tour routes in the temple has ...
Kai Zhou +3 more
doaj +1 more source
Effects of spatial configuration on contrast detection
Vision Research, 1998 We studied spatial integration at low contrasts by testing the detection thresholds of multi-Gabor element displays, examining configuration parameters such as orientation uniformity, contour smoothness, continuity, spacing and relative phase. We find that detectability depends on stimulus geometry and is constrained by collinearity and proximity ...
Bonneh, Yoram, Sagi, Dov
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source