Results 61 to 70 of about 8,118,965 (303)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Analysis of the Swiss style in relation to the formation of contemporary architecture in Nałęczów

Budownictwo i Architektura
Investment works are an integral part of the development of spa towns. The introduction of new, contemporary developments supporting the primary function is a crucial factor influencing economic growth. The ever-increasing interest in spa tourism exerts
Damian Hołownia, Aleksandra Sztorc
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

OptiFusionStack: A Physio-Spatial Stacking Framework for Shallow Water Bathymetry Integrating QAA-Derived Priors and Neighborhood Context

Remote Sensing
Conventional pixel-wise satellite-derived bathymetry (SDB) models face dual challenges: physical ambiguity from variable water quality and spatial incoherence from ignoring geographic context.
Wei Shen, Jinzhuang Liu, Xiaojuan Li, Dongqing Zhao, Zhongqiang Wu, Yibin Xu   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Attention Dynamics in Spatial-Temporal Contexts

Behavioral Sciences
This study systematically explored the impact of the spatial metaphor of time on attentional bias using visual order stimuli, ranging from fully order to 50% disorder, highlighting the regulatory roles of short-term memory and Gestalt perceptual grouping. Three experiments were conducted.
Wang, Yuying, Zhang, Xuemin, Van den Bussche, Eva   +2 more
openaire   +4 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Spatial context affects the Poggendorff illusion [PDF]

Perception & Psychophysics, 1993
The Poggendorff illusion has often been explained as purely an interaction between the parallels and the transversals. The present study demonstrates that additional spatial context exerts an influence on this illusion. In Experiment 1, we examined the effects of a surrounding tilted frame (complete and degraded versions) on collinearity adjustments in
M J, Spivey-Knowlton, B, Bridgeman
openaire   +2 more sources

A Vehicle Ride-Sharing Algorithm Assessing Passenger Satisfaction According to Spatial, Temporal, and Social Behavior Context Based on Real Data Sources

Future Transportation
Vehicle ride-sharing commute in smart cities is a service that has changed the way of citizens’ daily life and transportation schedule. Research in vehicle ride sharing aims to provide passengers with a comfortable living and well-being within the city ...
Theodoros Anagnostopoulos, Samson Rani Jino Ramson   +1 more
doaj   +1 more source

Context-independent expression of spatial code in hippocampus

Scientific Reports, 2022
The hippocampus plays a crucial role in the formation and retrieval of spatial memory across mammals and episodic memory in humans. Episodic and spatial memories can be retrieved irrespective of the subject’s awake behavioral state and independently of ...
S. Kapl, F. Tichanek, F. Zitricky, K. Jezek   +3 more
doaj   +1 more source