Results 81 to 90 of about 509,427 (264)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The influence of spatial and social context on cyclists’ anticipatory yielding behavior

Transportation Research Interdisciplinary Perspectives
This study examines how cyclists’ anticipatory yielding behavior is influenced by spatial and social contexts. While previous research has shown that cyclists’ yielding behavior is shaped by environmental context, a controlled study isolating the effects
Floor Bontje, Bas Spierings, Roland Geraerts, Taoufik Bakri, Leendert van Maanen, Christian P. Janssen   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Spatial Reasoning: The Role of Context in Learning.

, 2023
Spatial reasoning is an inherent aspect of everyday life. For example, spatial reasoning supports young children playing with blocks, older children learning about positioning on a sports field, and adults navigating where they need to go. Spatial reasoning is also a critical aspect of STEM (science, technology, engineering, mathematics, e.g., Wai ...
Resnick, Ilyse, Hegarty, Mary, Uttal, David, Lowrie, Tom   +3 more
openaire   +1 more source

Integrating local spatial outliers into context-aware spatial prediction models

GIScience & Remote Sensing
Improving spatial prediction remains a key challenge in geographical and environmental modeling, particularly in regions with strong spatial heterogeneity.
Jinyu Meng, Ziqin Zheng, Yongze Song
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Living and Dealing with Limited Opportunities: Social Disadvantage and Coping Strategies in Rural Peripheries

Sociální studia, 2016
In this article, manifestations of social disadvantage in peripheral rural settings in the Czech Republic are investigated. Based on the theory of local opportunity structures, the authors identify various aspects of the spatial context that intersect ...
Josef Bernard, Anja Decker, Renata Mikešová, Kateřina Vojtíšková   +3 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source