Results 91 to 100 of about 665,694 (315)
A spatial and temporal analysis of seat-belt usage and seat-belt laws [PDF]
Seat-belt usage has increased significantly in the US since the introduction of mandatory seat-belt usage laws in the 1980`s. This paper analyzes the impact of these laws on increasing seat-belt usage while controlling for other state-specific variables.
Majumdar, Arnab +2 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The spatiality of specialty coffee bars and the cognitive-cultural economy in Amsterdam
Cogent Social Sciences, 2016 Economic restructuring has led to the emergence of new socio-economic arrangements in cities based on the cognitive-cultural economy. Furthermore, the arrival of new middle classes in inner-cities has contributed to a renaissance of interest in urban ...
Reza Shaker Ardekani
doaj +1 more source
On the specification of spatial econometric models [PDF]
In this paper we discuss the specification process of a spatial econometric model. There are a lot of results available in a time series context, which form a very well structured phase, but little has been said when the domain of the model is the Space ...
Mur, Jesus
core
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
3D MIMO channel modeling and simulations
Dianxin kexue, 2016 The existing MIMO channel simulation models are based on two-dimensional（2D）plane and can’t match with a three-dimensional（3D）radio propagation environment.A 3D MIMO channel simulation platform based on WINNER channel model was set up.After adding the ...
Xiongwen ZHAO +4 more
doaj
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source