Results 101 to 110 of about 4,369,639 (344)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
International Journal of Health GeographicsBackground The COVID-19 pandemic caused substantial mortality in the United States with impacts unevenly distributed across the country. Official COVID-19-related death counts, however, almost certainly underrepresent the true impact of the pandemic due ...
Chen-Lun Kao, A. Stewart Fotheringham
doaj +1 more source
Spatial Data Model for Rural Planning and Land Management in Turkey
, 2021 Halil İbrahim Inan
openalex +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Remote SensingReal-time object detection on embedded unmanned aerial vehicles (UAVs) is crucial for emergency rescue, autonomous driving, and target tracking applications.
Hengyu Guo, Qunyong Wu, Yuhang Wang
doaj +1 more source
Clustering multivariate spatial data based on local measures of spatial autocorrelation. [PDF]
A growing interest in clustering spatial data is emerging in several areas, from local economic development to epidemiology, from remote sensing data to environment analyses. However, methods and procedures to face such problem are still lacking.
Luca Scrucca
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Sequential Hypothesis Testing With Spatially Correlated Presence-Absence Data [PDF]
, 2012 Elijah DePalma +3 more
openalex +1 more source