Results 61 to 70 of about 4,357,372 (295)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Frontiers in Marine ScienceIntroductionIn the future, China's mariculture must maintain its scale and improve quality. Crucial measures for achieving this goal are to optimize the layout of sea areas for aquaculture, strengthen the suitability assessment of marine aquaculture, and
Jinzhu Gao +4 more
doaj +1 more source
Selected Challenges From Spatial Statistics For Spatial Econometricians [PDF]
, 2012 Griffith and Paelinck (2011) present selected non-standard spatial statistics and spatial econometrics topics that address issues associated with spatial econometric methodology.
Griffith, Daniel A.
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Big Earth Data, 2021 Leaders are increasingly calling for improved decision support to manage human and environmental challenges in the 21st Century. The 17 United Nations Sustainable Development Goals (SDGs) provide a framing of these challenges, wherein 169 targets require
Zaffar Sadiq Mohamed-Ghouse +4 more
doaj +1 more source
Multi-Step Processing of Spatial Joins [PDF]
, 1994 Spatial joins are one of the most important operations for combining spatial objects of several relations. In this paper, spatial join processing is studied in detail for extended spatial objects in twodimensional data space.
Bernhard Seeger +11 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
UK open source crime data: accuracy and possibilities for research [PDF]
, 2014 In the United Kingdom, since 2011 data regarding individual police recorded crimes have been made openly available to the public via the police.uk website.
Ashby, M +4 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source