Results 71 to 80 of about 1,265,945 (262)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
ISPRS International Journal of Geo-Information, 2019 Cities are facing dramatic challenges due to population growth and the massive development of high-rises and complex structures, both above and below the ground surface. Decision-makers require access to an efficient land and property information system,
Hamed Olfat +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Impact of Political Economy on Land Administration Reform
LandPopulation growth, urbanization and climate change are all factors that have made it increasingly difficult for governments to manage, allocate and permit the development and use of the finite land resource that is available in any society.
Anthony Francis Burns +2 more
doaj +1 more source
Image-to-Point Cloud Registration using Camera Motion Generation and Monocular Depth Estimation [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information SciencesImage-to-point cloud (I2P) registration plays a vital role in applications requiring accurate spatial alignment between 2D images and their corresponding 3D point clouds.
M. Kamali +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
International Journal of Health GeographicsBackground The COVID-19 pandemic caused substantial mortality in the United States with impacts unevenly distributed across the country. Official COVID-19-related death counts, however, almost certainly underrepresent the true impact of the pandemic due ...
Chen-Lun Kao, A. Stewart Fotheringham
doaj +1 more source
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingWildfires cause substantial damage and present considerable risks to both natural ecosystem and human societies. A precise and prompt evaluation of wildfire-induced damage is crucial for effective postfire management and restoration.
Mingda Wu +4 more
doaj +1 more source