Results 61 to 70 of about 1,265,945 (262)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Underground SpaceUnderground land and property information is currently recorded, registered, and managed using two-dimensional (2D) datasets provided in survey plans. There are significant communication challenges associated with fragmented 2D land and property data in ...
Lanxuan Shen +3 more
doaj +1 more source
A Locating Method for Multi-Purposes HTs Based on the Boundary Network
IEEE Access, 2019 Recently, there are various methods for detecting the hardware trojans (HTs) in the integrated circuits (ICs). The circuit's logic representations of different types, structures, and functional characteristics should be different.
Chen Dong +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Viewpoint Selection for 3D Scenes in Map Narratives
ISPRS International Journal of Geo-InformationNarrative mapping, an advanced geographic information visualization technology, presents spatial information episodically, enhancing readers’ spatial understanding and event cognition. However, during 3D scene construction, viewpoint selection is heavily
Shichuan Liu +3 more
doaj +1 more source
Querying 3D Cadastral Information from BIM Models
ISPRS International Journal of Geo-Information, 2019 There has been significant research on the intersection of 3D cadastre and building information modelling (BIM) over the recent years. BIM provides a multidimensional environment for capturing, curating and communicating the physical and functional ...
Behnam Atazadeh +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Journal of Big DataRegion of interest (ROI) recommendation is essential for delivering personalized suggestions and optimizing resource allocation. This process involves analyzing users’ historical check-in data within location networks, which helps capture spatial ...
Qing Tang +5 more
doaj +1 more source