Results 71 to 80 of about 4,369,639 (344)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
A Locating Method for Multi-Purposes HTs Based on the Boundary Network
IEEE Access, 2019 Recently, there are various methods for detecting the hardware trojans (HTs) in the integrated circuits (ICs). The circuit's logic representations of different types, structures, and functional characteristics should be different.
Chen Dong +5 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
k-nearest neighbors prediction and classification for spatial data
, 2018 We propose a nonparametric predictor and a supervised classification based on the regression function estimate of a spatial real variable using k-nearest neighbors method (k-NN). Under some assumptions, we establish almost complete or sure convergence of
Ahmed, Mohamed-Salem +3 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Assessing spatial information access, use and sharing for catchment management in Australia [PDF]
, 2011 Spatial data plays an important role in many social, environmental, economic and political decisions and is increasingly acknowledged as a national resource essential for sustainable development.
Apan, Armando +2 more
core
Optimising Spatial and Tonal Data for PDE-based Inpainting
, 2015 Some recent methods for lossy signal and image compression store only a few selected pixels and fill in the missing structures by inpainting with a partial differential equation (PDE).
Doerr, Benjamin +8 more
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
An Overview of Spatial Econometrics
, 2016 This paper offers an expository overview of the field of spatial econometrics. It first justifies the necessity of special statistical procedures for the analysis of spatial data and then proceeds to describe the fundamentals of these procedures.
Tybl, Alexander J.
core +1 more source