Results 41 to 50 of about 613,971 (301)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Three-Dimensional Rule-Based City Modelling to Support Urban Redevelopment Process

ISPRS International Journal of Geo-Information, 2018
Multi-dimensional representation of urban settings has received a great deal of attention among urban planners, policy makers, and urban scholars. This is due to the fact that cities grow vertically and new urbanism strategies encourage higher density ...
Tyler Agius, Soheil Sabri, Mohsen Kalantari   +2 more
doaj   +1 more source

Development of Cost and Schedule Data Integration Algorithm Based on Big Data Technology

Applied Sciences, 2020
In the information age, the role of data in any industry is getting more and more important. In the construction industry, however, experts’ experience and intuition are still key determinants in decision-making, while other industries achieve tangible ...
Daegu Cho, Myungdo Lee, Jihye Shin
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Data-driven Strategies for Affordable Housing: A Hybrid Genetic Algorithm-Machine Learning Optimization Model in the Melbourne Metropolitan Area [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
The escalating rental crisis in Australia, rooted in demographic dynamics, a scarcity of lands suitable for development and the influence of interest rates and government subsidies, necessitates innovative solutions for housing affordability.
P. Jafary, P. Jafary, D. Shojaei, S. Pishgahi, A. Rajabifard, T. Ngo, T. Ngo   +6 more
doaj   +1 more source

Local Spatial Data Infrastructure as a Service for Efficient Spatial Management [PDF]

, 2012
Local spatial data infrastructure level (LSDI) covers managing of data in local administrative units (municipalities and cities). Precisely a local level is specific because the managed data are the most detailed, in the biggest scales, and therefore the
CETL Vlado, SISKO Darko, VESELIC BRUVO Jadranka   +2 more
core  

Scaling of transmission capacities in coarse-grained renewable electricity networks

, 2017
Network models of large-scale electricity systems feature only a limited spatial resolution, either due to lack of data or in order to reduce the complexity of the problem with respect to numerical calculations.
Greiner, Martin, Poulsen, Chris Risager, Schäfer, Mirko, Siggaard, Simon Bugge, Zhu, Kun   +4 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

3D Cadastral Database Systems—A Systematic Literature Review

ISPRS International Journal of Geo-Information
Cadastral databases have been used for over 20 years, but most contain 2D data. The increasing presence of high-rise buildings with modern architecture complicates the process of determining property rights, restrictions, and responsibilities.
Javad Shahidinejad, Mohsen Kalantari, Abbas Rajabifard   +2 more
doaj   +1 more source