Results 41 to 50 of about 271,473 (265)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Sensors, 2023 This paper aims to describe the outcomes of the Main10ance project, which focused on developing an integrated HBIM-GIS platform to support the maintenance and conservation plans for the historic built heritage. The pilot case is the UNESCO complex of the
Francesca Matrone +3 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
A Hierarchical Spatial Network Index for Arbitrarily Distributed Spatial Objects
ISPRS International Journal of Geo-Information, 2021 The range query is one of the most important query types in spatial data processing. Geographic information systems use it to find spatial objects within a user-specified range, and it supports data mining tasks, such as density-based clustering. In many
Xiangqiang Min +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and implementation of a spatial database for analysis of wheelchair accessibility
Geospatial HealthAccessibility is an essential consideration in the design of public spaces, and commonly referred to as ‘pedestrian accessibility’ when walking is the primary mode of transportation.
Peter Nezval, Takeshi Shirabe
doaj +1 more source
GeoSpark SQL: An Effective Framework Enabling Spatial Queries on Spark
ISPRS International Journal of Geo-Information, 2017 In the era of big data, Internet-based geospatial information services such as various LBS apps are deployed everywhere, followed by an increasing number of queries against the massive spatial data.
Zhou Huang +3 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Study of spatial database construction of smart mine
Gong-kuang zidonghua, 2014 The paper discussed construction models of spatial database of smart mine based on analysis of composition and characteristics of mine spatial data, and expounded construction of spatial data framework of smart mine from three aspects which are spatial ...
WANG Li, DU Jiusheng, JING Haitao
doaj +1 more source