Results 71 to 80 of about 5,687,015 (319)

Query processing of spatial objects: Complexity versus Redundancy [PDF]

open access: yes, 1993
The management of complex spatial objects in applications, such as geography and cartography, imposes stringent new requirements on spatial database systems, in particular on efficient query processing. As shown before, the performance of spatial query
A. Braun   +9 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Spatial Model of Optimization Applied in the Distributed Generation Photovoltaic to Adjust Voltage Levels

open access: yesEnergies, 2021
The main objective of this work is to develop a methodology for analyzing the quality of the voltage level in the distribution power grid to identify and reduce the violations of voltage limits through the proposition of optimal points for the allocation
José A. G. Cararo   +6 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Enhancing Disaster Management: Development of a Spatial Database of Day Care Centers in the USA

open access: yesISPRS International Journal of Geo-Information, 2015
Children under the age of five constitute around 7% of the total U.S. population, and represent a segment of the population that is totally dependent on others for day-to-day activities.
Nagendra Singh   +2 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Perancangan Data Warehouse dan Penerapan Teknik Clustering Spatial pada Wesel: Studi Kasus PT XXX

open access: yesComTech, 2013
By setting up the right service and product for the customer, the company may increase its marketing effectiveness as well as sales. For that purpose, information on company’s product and sales is highly needed in order to help on decision making ...
Arief Dwi Hartadi, Oktalia Juwita
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Building a Spatial Database by Developing a Work Environment to Accomplish the Automatic Transfer Process for Remote Sensing Data from Raster to Linear [PDF]

open access: yesAl-Rafidain Journal of Computer Sciences and Mathematics, 2010
In this paper a develop an working environment for building spatial database by utilizing ArcView Geographic Information System software package and IDRISI software package for remotely sensed images processing is obtained.
Diaa Al-Berhawi
doaj   +1 more source

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