Results 81 to 90 of about 5,704,475 (316)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Towards a Scalable Dynamic Spatial Database System [PDF]
, 2012 With the rise of GPS-enabled smartphones and other similar mobile devices, massive amounts of location data are available. However, no scalable solutions for soft real-time spatial queries on large sets of moving objects have yet emerged.
Diaconu, Raluca +2 more
core +3 more sources
Evaluation of Topological Consistency in CityGML
ISPRS International Journal of Geo-Information, 2019 Boundary representation models are data models that represent the topology of a building or city model. This leads to an issue in combination with geometry, as the geometric model necessarily has an underlying topology.
Anna Giovanella +2 more
doaj +1 more source
Energies, 2021 The main objective of this work is to develop a methodology for analyzing the quality of the voltage level in the distribution power grid to identify and reduce the violations of voltage limits through the proposition of optimal points for the allocation
José A. G. Cararo +6 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Query processing of geometric objects with free form boundarie sin spatial databases [PDF]
, 1993 The increasing demand for the use of database systems as an integrating factor in CAD/CAM applications has necessitated the development of database systems with appropriate modelling and retrieval capabilities.
Fahldiek, Andreas +3 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Linear separability in spatial databases [PDF]
Knowledge and Information Systems, 2017 Given two point sets $R$ and $B$ in the plane, with cardinalities $m$ and $n$, respectively, and each set stored in a separate R-tree, we present an algorithm to decide whether $R$ and $B$ are linearly separable. Our algorithm exploits the structure of the R-trees, loading into the main memory only relevant data, and runs in $O(m\log m + n\log n)$ time
Gutiérrez, Gilberto +2 more
openaire +2 more sources