Results 121 to 130 of about 3,205,346 (307)
Spatial Development Follows Digitization
, 2018 Two economic sectors, which massively depend on mobility, are considered in this article: logistics and tourism. The Fehmarn-Belt Fixed Link Area will be a challenge for these economic sectors. Educational institutions provide the skillsets for managers in this new emerging region.
Rettig, Lars, Friedrichsen, Morten
openaire +3 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Spatial Inequality and Development [PDF]
, 2005 Abstract Drawing on data from 25 countries from all regions of the world, this book addresses questions that have become very important in recent years, as the spatial dimensions of inequality have begun to attract considerable policy interest; what is spatial inequality? Why does it matter?
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A new paradigm of the EU regional development in the context of the Poland’s National Spatial Development Concept [PDF]
New factors inspiring spatial and regional policies in Poland have come out in the recent years. They complement the traditional, hardly spatial, paradigm of the socio-economic development with the concept of place-based economics. The paradigm shift was
Jacek Szlachta, Jacek Zaucha
core
Checkpoint blockade and the stem‐like T cell trade‐off
Molecular Oncology, EarlyView.Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley +1 more source
EU AGRICULTURAL POLICY AND THE REGIONAL DIFFERENTIATION OF AGRICULTURE IN POLAND [PDF]
The paper addresses the “spatial” structure of agriculture in Poland whose spatial development is analysed from the beginning of the transition towards a market economy up until the country’s forthcoming accession to the EU and the correlated ...
Riccardo Crescenzi
core
Commercial Applications Multispectral Sensor System [PDF]
, 1993 NASA's Office of Commercial Programs is funding a multispectral sensor system to be used in the development of remote sensing applications. The Airborne Terrestrial Applications Sensor (ATLAS) is designed to provide versatility in acquiring spectral and ...
Birk, Ronald J., Spiering, Bruce
core +1 more source