FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Spatiotemporal correlation analysis between carbon emission intensity and intensive use level of construction land at county scale in Chongqing of China. [PDF]
Carbon Balance ManagWei C, Zongyuan L, Minyu Z, Runxia G.
europepmc +1 more source
Spatial Inequality and Development
, 2016 Thirteen papers, presented at a conference held at the London School of Economics in June 2002, study spatial inequality; in a global context, explore the evolution and determinants of spatial inequality, and consider what policy response, if any, would be appropriate.
openaire +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Investigating spatial distribution of kindergartens in Chinese cities: A spatial stratified heterogeneity approach. [PDF]
PLoS OneZhang B, He S, Jiang L.
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Spatial transcriptomics of developing human lungs defines cellular phenotypes associated with age, lineage and location. [PDF]
Sci RepRen Y +5 more
europepmc +1 more source
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Integrated eco-economic zoning and carbon neutrality zoning into the PLUS model to simulate land use change in the Guangdong-Hong Kong-Macao Greater Bay Area. [PDF]
PeerJZhan M, Xu Y, Yu Y, Liu C, Wang F.
europepmc +1 more source