Results 111 to 120 of about 3,219,480 (302)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Spatial Effect of Air Pollution Governance on Labor Productivity: Evidence from 262 Chinese Cities. [PDF]

Int J Environ Res Public Health, 2022
Ren F, Zhu Y, Le D.
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Role of mammography accessibility, deprivation and spatial effect in breast cancer screening participation in France: an observational ecological study. [PDF]

Int J Health Geogr, 2022
Prajapati N, Soler-Michel P, Vieira VM, Padilla CM.   +3 more
europepmc   +1 more source

Integrating spatial dependence into stochastic frontier analysis [PDF]

An approach to incorporate spatial dependence into Stochastic Frontier analysis is developed and applied to a sample of 215 dairy farms in England and Wales.
Areal, Francisco J, Balcombe, Kelvin, Tiffin, R   +2 more
core   +1 more source

Spatial features of non-thermal SZ effect in galaxy clusters

, 2002
We investigate the spatial behaviour of the total comptonization parameter $y_{tot}$ evaluated for a galaxy cluster containing two population of electrons: the thermal population, with energy around some KeV and whose trace is evident in the X-ray ...
Colafrancesco, S., Marchegiani, P., Palladino, E.   +2 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Spatial effect of transportation infrastructure on regional circular economy: evidence from Guangdong-Hong Kong-Macao Greater Bay Area. [PDF]

Environ Sci Pollut Res Int, 2023
Wang L, Wu Z, Ye H, Feng W.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Study on Zonal Support Mechanism and the Surrounding Rock Control Technology of Rock Roadway Excavated by TBM in Coal Mine

Energy Science & Engineering
Tunnel boring machine (TBM) has been increasingly used for excavating rock roadways in coal mines. However, the slower speed of support installation, compared to the cutterhead's fast rock‐breaking capability, limits the overall excavation speed of rock ...
Zhao Chen, Sheng Zhang, Yiqiang Lu, Zhanbiao Yang, Longfei Wang, Fei He   +5 more
doaj   +1 more source