Results 61 to 70 of about 35,651 (167)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Impact of Microclimate on Perception and Physical Activities in Public Spaces of New Urban Areas in Beijing, China

Buildings
The development of new urban areas in Beijing has alleviated overcrowding in old urban centers and has ample public spaces for recreational activities. However, these public spaces are not ideally designed and have not been as successful as expected. Few
Mo Han, Yani Fang, Li Yi, Siyi Liu
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Characterizing Role of Spatial Features in Improving Mangrove Classification—A Case Study over the Mesoamerican Reef Region

Remote Sensing
Mangrove forests are among the world’s most vital coastal ecosystems. Mapping mangrove cover from local to global scales using spectral data and machine learning models is a well-established method.
Suvarna M. Punalekar, A. Justin Nowakowski, Steven W. J. Canty, Craig Fergus, Qiongyu Huang, Melissa Songer, Grant M. Connette   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conventional to Deep Ensemble Methods for Hyperspectral Image Classification: A Comprehensive Survey

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Hyperspectral image classification (HSIC) has become a hot research topic. Hyperspectral imaging (HSI) has been widely used in a wide range of real-world application areas due to the in-depth spectral information stored within each pixel. Noticeably, the
Farhan Ullah, Irfan Ullah, Rehan Ullah Khan, Salabat Khan, Khalil Khan, Giovanni Pau   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

STFF-CANet Diagnosis Model of Aero-Engine Surge Based on Spatio-Temporal Feature Fusion

Aerospace
Aero engine surge diagnosis is a key technology in engine health management, and its diagnostic accuracy is of great significance for ensuring operational safety.
Chunyan Hu, Yafeng Shen, Qingwen Zeng, Gang Xu, Jiaxian Sun, Keqiang Miao   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source