Results 51 to 60 of about 530,690 (264)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Object spatial frequencies, retinal spatial frequencies, noise, and the efficiency of letter discrimination

open access: yesVision Research, 1991
To determine which spatial frequencies are most effective for letter identification, and whether this is because letters are objectively more discriminable in these frequency bands or because can utilize the information more efficiently, we studied the 26 upper-case letters of English. Six two-octave wide filters were used to produce spatially filtered
D H, Parish, G, Sperling
openaire   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Spatial Frequency Discrimination: Effects of Age, Reward, and Practice

open access: yesPLOS ONE, 2017
Social interaction starts with perception of the world around you. This study investigated two fundamental issues regarding the development of discrimination of higher spatial frequencies, which are important building blocks of perception. Firstly, it mapped the typical developmental trajectory of higher spatial frequency discrimination.
Carlijn van den Boomen   +1 more
openaire   +5 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Study of Efficiency Fractal Optical Modulator for insulator material by testing modulation transfer function

open access: yesمجلة علوم ذي قار, 2019
Chopper is an important component in optical system. It represents a device, which changes the angle between the coordinate and vision lines of the target for the electrical signal. The chopper modulates the optical signal by a frequency dependent on the
Mohammed L. Jabbar   +1 more
doaj   +2 more sources

The Role of Spatial Frequency Information in Face Classification by Race

open access: yesFrontiers in Psychology, 2017
It was found that face classification by race is more quickly for other-race than own-race faces (other-race classification advantage, ORCA). Controlling the spatial frequencies of face images, the current study investigated the perceptual processing ...
Guoping Zhang   +4 more
doaj   +1 more source

Spatial vision of the achromat: spatial frequency and orientation‐specific adaptation. [PDF]

open access: yesThe Journal of Physiology, 1988
1. The psychophysical technique of selective adaptation to stationary sine‐wave gratings of varying spatial frequency and orientation was used to investigate the central processing of spatial information in the visual system of the complete achromat. 2.
Greenlee, Mark W.   +2 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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