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Spatial Transcriptomics for Tumor Heterogeneity Analysis

open access: yesFrontiers in Genetics, 2022
The molecular heterogeneity of cancer is one of the major causes of drug resistance that leads to treatment failure. Thus, better understanding the heterogeneity of cancer will contribute to more precise diagnosis and improved patient outcomes.
Rongqin Ke
exaly   +3 more sources

An optimal parameters-based geographical detector model enhances geographic characteristics of explanatory variables for spatial heterogeneity analysis: cases with different types of spatial data

open access: yesGIScience and Remote Sensing, 2020
Spatial heterogeneity represents a general characteristic of the inequitable distributions of spatial issues. The spatial stratified heterogeneity analysis investigates the heterogeneity among various strata of explanatory variables by comparing the ...
Yong Ge, Jinfeng Wang, Chengdong Xu
exaly   +2 more sources

Spatial protein heterogeneity analysis in frozen tissues to evaluate tumor heterogeneity

open access: yesPLoS ONE, 2021
A new workflow for protein-based tumor heterogeneity probing in tissues is here presented. Tumor heterogeneity is believed to be key for therapy failure and differences in prognosis in cancer patients. Comprehending tumor heterogeneity, especially at the
Anna Fomitcheva-Khartchenko   +4 more
doaj   +2 more sources

Modeling of spatial stratified heterogeneity

open access: yesGIScience & Remote Sensing, 2022
Spatial stratified heterogeneity (SSH) refers to the geographical phenomena in which the geographical attributes within-strata are more similar than the between-strata, which is ubiquitous in the real world and offers information implying the causation ...
Jiangang Guo   +3 more
doaj   +1 more source

Extraction of Continuous and Discrete Spatial Heterogeneities: Fusion Model of Spatially Varying Coefficient Model and Sparse Modelling

open access: yesISPRS International Journal of Geo-Information, 2022
Geospatial phenomena often have spatial heterogeneity, which is caused by differences in the data generation process from place to place. There are two types of spatial heterogeneity: continuous and discrete, and there has been much discussion about how ...
Ryo Inoue, Koichiro Den
doaj   +1 more source

The Spatial Effects of Regional Poverty: Spatial Dependence, Spatial Heterogeneity and Scale Effects

open access: yesISPRS International Journal of Geo-Information, 2023
Recognizing the spatial effects of regional poverty is essential for achieving sustainable poverty alleviation. This study investigates these spatial effects and their determinants across three distinct administrative levels within Hubei Province, China.
Mengxiao Liu   +3 more
doaj   +1 more source

Spatial heterogeneity of the shorebird gastrointestinal microbiome [PDF]

open access: yesRoyal Society Open Science, 2020
The gastrointestinal tract (GIT) consists of connected structures that vary in function and physiology, and different GIT sections potentially provide different habitats for microorganisms.
Kirsten Grond   +2 more
doaj   +1 more source

A Lacunarity‐Based Index for Spatial Heterogeneity

open access: yesEarth and Space Science, 2022
Characterizing spatial heterogeneity is fundamental in numerous areas, yet defining spatial patterns often depends on qualitative assessments or a priori knowledge.
R. Scott   +4 more
doaj   +1 more source

Grazing effects on shrub-induced resource islands and herbaceous vegetation heterogeneity in sagebrush-steppe communities

open access: yesGlobal Ecology and Conservation, 2022
Spatial heterogeneity in plant communities promotes coexistence and diversity by providing a variety of niches for different species. In shrub-steppe communities, shrubs create distinct microsites under their canopies (canopy microsites) compared to ...
Kirk W. Davies   +2 more
doaj   +1 more source

Combined effects of soil 3D spatial heterogeneity and biotic spatial heterogeneity (plant clumping) on ecosystem processes in grasslands

open access: yesEcology and Evolution, 2023
Soil heterogeneity has been shown to enhance plant diversity, but its effect on grassland productivity is less clear. Even less is known about the effect of plant clumping (intraspecific aggregation) and its potential interaction with soil heterogeneity.
O. Vindušková   +5 more
doaj   +1 more source

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