Non-genetic evolution drives lung adenocarcinoma spatial heterogeneity and progression.
Cancer evolution determines molecular and morphological intra-tumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphologically diverse ...
Daniele Tavernari +12 more
semanticscholar +1 more source
A Lacunarity‐Based Index for Spatial Heterogeneity
Characterizing spatial heterogeneity is fundamental in numerous areas, yet defining spatial patterns often depends on qualitative assessments or a priori knowledge.
R. Scott +4 more
doaj +1 more source
Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types 1 , 2 . Intratumoral host–microbiota studies have so far largely relied on bulk tissue analysis 1 – 3 , which obscures the spatial ...
J. L. Galeano Niño +13 more
semanticscholar +1 more source
Heterogeneous timescales are spatially represented [PDF]
There is little doubt that cognitive processes involved in perceiving and comparing the duration of the sounds played by a musical instrument are very different from those involved, for instance, in recalling when our latest holidays took place. However, despite their clear difference, we ascribe both processes to the time domain, either in the form of
BONATO, MARIO, UMILTA', CARLO ARRIGO
openaire +3 more sources
Effects of Plateau Pika Disturbance on the Spatial Heterogeneity of Vegetation in Alpine Meadows
Herbivory is one of the important factors that influence spatial heterogeneity of vegetation in grasslands. In this study, we focused on plateau pika (Ochotona curzoniae) to investigate the effects of the presence of small semi-fossorial herbivores and ...
Jie Li +3 more
doaj +1 more source
A Bayesian spatial random effects model characterisation of tumour heterogeneity implemented using Markov chain Monte Carlo (MCMC) simulation [PDF]
The focus of this study is the development of a statistical modelling procedure for characterising intra-tumour heterogeneity, motivated by recent clinical literature indicating that a variety of tumours exhibit a considerable degree of genetic spatial ...
Grech-Sollars, M, King, MD
core +1 more source
Landscape structures affect pests, depending on compositional heterogeneity (the number and proportions of different habitats), configurational heterogeneity (spatial arrangement of habitats), and spatial scales.
Zhi Wen +15 more
doaj +1 more source
Spatial heterogeneity of the shorebird gastrointestinal microbiome [PDF]
The gastrointestinal tract (GIT) consists of connected structures that vary in function and physiology, and different GIT sections potentially provide different habitats for microorganisms.
Kirsten Grond +2 more
doaj +1 more source
Species richness-environment relationships of European arthropods at two spatial grains : habitats and countries [PDF]
We study how species richness of arthropods relates to theories concerning net primary productivity, ambient energy, water-energy dynamics and spatial environmental heterogeneity.
Ben A. Woodcock +8 more
core +7 more sources
Modeling Spatial Interaction in Stochastic Frontier Analysis
We compare farm level efficiency rankings derived from non-spatial and a variety of spatial model specifications that account for unobserved heterogeneity in both the production and the efficiency sides of the stochastic frontier model in an empirical ...
Francisco J. Areal, Valerien O. Pede
doaj +1 more source

