Results 71 to 80 of about 2,238,587 (282)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Exploring the Use of Landmarks to Aid Pedestrian Wayfinding
Applied SciencesWhen wayfinding with mobile maps, the acquisition of spatial knowledge can be limited by relying on automated route instructions and the small map on the screen.
Blair Kuys, Andrew Haig, Mozammel Mridha
doaj +1 more source
Cognitive and cartographic representations: towards a comprehensive approach
Cybergeo, 2002 In order to clearly understand the cognitive representations of the urban space, this paper presents an approach in three steps: identification, which highlights the importance of a place; its location more or less exact which indicates the level of the ...
Colette Cauvin
doaj +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Birds of a Feather - Better Together? Exploring the Optimal Spatial Distribution of Ethnic Inventors [PDF]
We examine how the spatial and social proximity of inventors affects knowledge flows, focusing especially on how the two forms of proximity interact.
Ajay Agrawal, Devesh Kapur, John McHale
core
Workmen’s Compensation: Contagious Disease Held Compensable [PDF]
, 1961 Knowledge about dispersion is of utmost importance for understanding populations’ reaction to changes in the environment. Expansion of a population range brings with it both spatial sorting and over time, spatial selection.
Brengdahl, Martin
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source