Results 71 to 80 of about 2,234,141 (283)
Cognitive and cartographic representations: towards a comprehensive approach
Cybergeo, 2002 In order to clearly understand the cognitive representations of the urban space, this paper presents an approach in three steps: identification, which highlights the importance of a place; its location more or less exact which indicates the level of the ...
Colette Cauvin
doaj +1 more source
Neural codes for one’s own position and direction in a real-world “vista” environment [PDF]
, 2018 Humans, like animals, rely on an accurate knowledge of one’s spatial position and facing direction to keep orientated in the surrounding space. Although previous neuroimaging studies demonstrated that scene-selective regions (the parahippocampal place ...
Boccia, Maddalena +3 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Modelling the folk theorem of spatial economics: a heterogeneous regional growth model [PDF]
During the last year, the research field of spatial economic has rapidly increased. There is consensus that the economic performance of a region depends not only on its own potential, but also on the development of their neighbouring regions.
Torben Klarl
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Birds of a Feather - Better Together? Exploring the Optimal Spatial Distribution of Ethnic Inventors [PDF]
We examine how the spatial and social proximity of inventors affects knowledge flows, focusing especially on how the two forms of proximity interact.
Ajay Agrawal, Devesh Kapur, John McHale
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
KBGIS-2: A knowledge-based geographic information system [PDF]
The architecture and working of a recently implemented knowledge-based geographic information system (KBGIS-2) that was designed to satisfy several general criteria for the geographic information system are described.
Agarwal, P. +3 more
core +1 more source