Results 111 to 120 of about 9,340,776 (309)

WAG/Rij ve Sprague Dawley Sıçanlarında Hafıza ve Öğrenme: “Irksal Deneyimin” Özellikle Epilepsi Yatkınlığının Üzerindeki Etkisinin Araştırılması

Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
Bu araştırma, genetik varyasyonların sıçanlarda öğrenmeyi, kısa süreli hafızayı ve uzun süreli hafızayı nasıl etkilediğini araştırmayı amaçlamıştır. Özellikle, doğal olarak epilepsiye yatkın olan WAG/Rij (WR) sıçanlarını Sprague-Dawley (SD) sıçanlarıyla ...
Burcu Çevreli, Öznur Özge Özcan
doaj   +1 more source

Learned Spatial Schemas and Prospective Hippocampal Activity Support Navigation After One-Shot Learning

Frontiers in Human Neuroscience, 2018
Prior knowledge structures (or schemas) confer multiple behavioral benefits. First, when we encounter information that fits with prior knowledge structures, this information is generally better learned and remembered.
Marlieke T. R. van Kesteren, Marlieke T. R. van Kesteren, Thackery I. Brown, Thackery I. Brown, Anthony D. Wagner   +4 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Enhancing spatial learning during driving: the role of 3D navigation interface visualization in AR-HUD

Geo-spatial Information Science
The style of geovisualization influences drivers’ cognition, decision-making, and spatial learning abilities. With the advancement of in-vehicle navigation technologies, Augmented Reality Head-Up Displays (AR-HUDs) have been widely applied in driving ...
Xun Xu, Jing Yang, Sixing Zhao, Yajun Li, Linyan Ren, Mengniu Li, Biao Yan   +6 more
doaj   +1 more source

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images.

Cell Reports, 2018
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images from 13 TCGA
J. Saltz, Rajarsi R. Gupta, L. Hou, T. Kurç, P. Singh, Vu Nguyen, D. Samaras, K. Shroyer, Tianhao Zhao, R. Batiste, John S. Van Arnam, I. Shmulevich, A. Rao, A. Lazar, Ashish Sharma, V. Thorsson   +15 more
semanticscholar   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2015
Hepatic encephalopathy (HE) is one of the primary complications of liver cirrhosis. Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and ...
M. Johansson, A. Agustí, M. Llansola, C. Montoliu, J. Strömberg, E. Malinina, G. Ragagnin, M. Doverskog, T. Bäckström, V. Felipo   +9 more
semanticscholar   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

Journal of Neuroinflammation, 2015
BackgroundThere are no specific treatments for the neurological alterations of cirrhotic patients with minimal hepatic encephalopathy (MHE). Rats with MHE due to portacaval shunt (PCS) show impaired spatial learning.
V. Hernández‐Rabaza, A. Agustí, A. Cabrera-Pastor, Santos Fustero, Oscar Delgado, Lucas Taoro‐González, C. Montoliu, M. Llansola, V. Felipo   +8 more
semanticscholar   +1 more source

Lived and Care Experiences of Chronic Musculoskeletal Shoulder Pain in Australian Adults: A Qualitative Study

Arthritis Care &Research, EarlyView.
Objective Australian evidence on lived and care experiences of chronic musculoskeletal shoulder pain (CMSP), irrespective of disorder classification or disease, is limited. However, such evidence is important for person‐centered care and informing local service pathways and care guidelines or standards.
Sonia Ranelli, Joanne E. Jordan, Ilana N. Ackerman, Alison Thorpe, Jennifer G. Persaud, Linda J. Woodhouse, Jason Chua, Ben Horgan, Andrew M. Briggs   +8 more
wiley   +1 more source