Results 51 to 60 of about 1,675,665 (284)
Why Consultations? The public participation in water management and local spatial planning in two Polish cases [PDF]
, 2016 Despite many novelties in participation: participatory budgeting, citizens jury, deliberatice poll etc. the engagement of different stakeholders’ groups in the decision making processes concerning detailed planning issues (local spatial management plans,
Matczak, Piotr +3 more
core +1 more source
Affordances of Historic Urban Landscapes: an Ecological Understanding of Human Interaction with the Past [PDF]
, 2014 Heritage has been defined differently in European contexts. Despite differences, a common challenge for historic urban landscape management is the integration of tangible and intangible heritage. Integration demands an active view of perception and human-
Alves, Susana
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Spatial prioritization of conservation management [PDF]
Conservation Letters, 2011 Abstract We develop a high‐resolution conservation prioritization analysis for New Zealand's rivers and streams that simultaneously consider both the present state (representation) of ecosystems, and the prioritization of management actions designed to mitigate ongoing human impacts on their expected future state (
Moilanen, Atte +2 more
openaire +1 more source
Spatial uncertainty and structuration effects on preventive management of locust plagues: a multi-agent perspective [PDF]
, 2019 The spatial structure of locust outbreaks is a major item of planning and success of locust preventive management strategies. Indeed, preventive management relies on where and when survey teams have to be sent to explore and report the biotope situation ...
Gay, Pierre-Emmanuel +2 more
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Synergies of planning for forests and planning for Natura 2000: Evidences and prospects from northern Italy [PDF]
, 2018 Improvements in the management of Natura 2000 sites are essential to achieve the targets set out by the Habitats and Birds Directives of the European Union.
Campagnaro, Thomas +3 more
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Human Resource Management Diffusion and Productivity Imbalances [PDF]
, 2019 In this study, we explore spatial variance in management practices and assess its potential contribution to regional imbalances in productivity. The research builds on a growing body of evidence which indicates that differences in management practices ...
Askenazy, P., Bryson, A., Forth, J.
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source