Results 31 to 40 of about 13,924 (215)

A pathway for spatial memory encoding [PDF]

Learning & Behavior, 2016
The medial prefrontal cortex has been shown to play a role for rodents in successful completion of tasks that require spatial memory, but the pathways responsible for the transmission of spatial information to the mPFC, and the nature and timing of such information, are unknown. Recently, Spellman, Rigotti, Ahmari, Fusi, Gogos, and Gordon (Nature, 522,
Brett M, Gibson, Robert, Mair
openaire   +2 more sources

The entorhinal spatial map integrates visual identity information of landmarks

Nature Communications
Landmarks guide navigation by providing information through their location and identity. The medial entorhinal cortex (MEC) is well known for representing landmark location, but whether it also encodes landmark identity remains unclear.
Garret Wang, Farid Shahid, Taylor J. Malone, Jean Tyan, Kyle Cekada, Lujia Chen, Yi Gu   +6 more
doaj   +1 more source

Sex-dependent effects of psychedelics: review of evidence from rodent models

Frontiers in Psychiatry
Classic psychedelics, including psilocybin, LSD, DMT, 5-MeO-DMT, mescaline, and phenethylamines such as DOI, exert their core effects through 5-HT2A receptor agonism, inducing widespread neurobiological and behavioral changes relevant to psychiatric ...
Rafał Marecki, Wiktoria Zaniewska, Adam Hamed, Napoleon Waszkiewicz, Jacob J. Baker, Kacper Łukasiewicz, Kacper Łukasiewicz, Kacper Łukasiewicz   +7 more
doaj   +1 more source

Molecular mechanisms for the destabilization and restabilization of reactivated spatial memory in the Morris water maze

Molecular Brain, 2011
Background Memory retrieval is not a passive process. Recent studies have shown that reactivated memory is destabilized and then restabilized through gene expression-dependent reconsolidation. Molecular studies on the regulation of memory stability after
Kim Ryang, Moki Ryouichi, Kida Satoshi
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Stroboscopic light stimulation as a controllable probe of the psilocybin state: a mechanistic framework and a falsifiable prediction

Frontiers in Pharmacology
Stroboscopic light stimulation (SLS) and psilocybin each induce altered states whose phenomenology and neurophysiology partly overlap, including posterior alpha-band changes and visual imagery.
Kacper Żełabowski, Tomasz Wieczorek, Adam Hamed   +2 more
doaj   +1 more source

Orienteering experts report more proficient spatial processing and memory across adulthood.

PLoS ONE, 2023
The closest surrogate to hunter-gather activity is the sport of orienteering, which naturally and simultaneously combines high-intensity interval exercise with navigation.
Emma E Waddington, Jennifer J Heisz
doaj   +1 more source

Billiards with Spatial Memory

Physical Review Letters
Many classes of active matter develop spatial memory by encoding information in space, leading to complex pattern formation. It has been proposed that spatial memory can lead to more efficient navigation and collective behaviour in biological systems and influence the fate of synthetic systems.
Thijs Albers, Stijn Delnoij, Nico Schramma, Maziyar Jalaal   +3 more
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A consistent map in the medial entorhinal cortex supports spatial memory

Nature Communications
The medial entorhinal cortex (MEC) is hypothesized to function as a cognitive map for memory-guided navigation. How this map develops during learning and influences memory remains unclear. By imaging MEC calcium dynamics while mice successfully learned a
Taylor J. Malone, Nai-Wen Tien, Yan Ma, Lian Cui, Shangru Lyu, Garret Wang, Duc Nguyen, Kai Zhang, Maxym V. Myroshnychenko, Jean Tyan, Joshua A. Gordon, David A. Kupferschmidt, Yi Gu   +12 more
doaj   +1 more source