FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
A spatial model of YAP/TAZ signaling reveals how stiffness, dimensionality, and shape contribute to emergent outcomes. [PDF]
Proc Natl Acad Sci U S A, 2021 Scott KE, Fraley SI, Rangamani P.
europepmc +1 more source
Varying dataset resolution alters predictive accuracy of spatially explicit ensemble models for avian species distribution [PDF]
, 2018 Claire Curry +3 more
openalex +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
A simplified tempo-spatial model to predict airborne pathogen release risk in enclosed spaces: An Eulerian-Lagrangian CFD approach. [PDF]
Build Environ, 2022 Mirzaei PA +4 more
europepmc +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
A spatial model for assessment of urban vulnerability in the light of the UN New Urban Agenda guidelines: case study of Assiut City, Egypt. [PDF]
Model Earth Syst Environ, 2022 Effat HA, Ramadan MS, Ramadan RH.
europepmc +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
I. Age-depentent spatially distributed two sex model of population dynamics with pair formation and dynamic analysis via computer simulations : II. An ecological model for red tide plankton and numerical simulation : III. Flow analysis around structures in environmental fluids and its application to environmental restoration technology [PDF]
, 2004 Shinnosuke Ôharu +11 more
openalex +1 more source