Results 61 to 70 of about 2,551,132 (297)

Robot-Assisted Arm Training in Stroke Individuals With Unilateral Spatial Neglect: A Pilot Study

Frontiers in Neurology, 2021
Background: Robot-assisted arm training (RAT) is an innovative exercise-based therapy that provides highly intensive, adaptive, and task-specific training, yet its effects for stroke individuals with unilateral spatial neglect remain to be explored.
Ze-Jian Chen, Ze-Jian Chen, Ming-Hui Gu, Ming-Hui Gu, Chang He, Cai-Hua Xiong, Jiang Xu, Jiang Xu, Xiao-Lin Huang, Xiao-Lin Huang   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Factors Affecting the Clinical Measurement of Visuo-Spatial Neglect

Behavioural Neurology, 1992
The present study examined a battery of tests to evaluate unilateral spatial neglect; the tests included different tasks involving several modalities of spatial exploration mapping perceptual, motor, attentional and personal or extrapersonal space ...
L. Pizzamiglio, C. Bergego, P. Halligan, V. Homberg, I. Robertson, E. Weber, B. Wilson, P. Zoccolotti, G. Deloche   +8 more
doaj   +1 more source

The automatic pilot of the hand is unbalanced by visual neglect [PDF]

, 2010
This article discusses the automatic pilot of the hand being unbalanced by visual ...
McIntosh, R.D., McIntosh, Robert D., Rossit, Stephanie, Monika Harvey, Butler, Stephen H., Malhotra, Paresh, McIntosh, Robert D, Paresh Malhotra, Butler, Stephen H, Harvey, M., Harvey, Monika, Stephanie Rossit, Butler, S.H., Robert D. McIntosh, Stephen H. Butler, Rossit, S., Malhotra, P.   +16 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Visual attention with implications for unilateral spatial neglect. [PDF]

, 1992
Recent models of visual attention (eg. Rizzolatti et al., 1987) have suggested that a similar system orients visual attention as is used to produce a saccadic eye movement. This thesis provides further support for the link between the attentional and eye
Walker, R, Walker, Robin
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Negami: An Augmented Reality App for the Treatment of Spatial Neglect After Stroke

JMIR Serious Games, 2023
BackgroundA widely applied and effective rehabilitation method for patients experiencing spatial neglect after a stroke is “visual exploration training.” Patients improve their ipsilesional bias of attention and orientation by ...
Britta Stammler, Kathrin Flammer, Thomas Schuster, Marian Lambert, Hans-Otto Karnath   +4 more
doaj   +1 more source