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Expansion omics: from expansion microscopy to spatial omics [PDF]
Molecular Systems BiologyTissue expansion, originally developed for super-resolution imaging, has become a foundation for expansion omics (ExO), a growing field that uses physical tissue expansion to enable spatially resolved omics profiling.
Zhen Dong +3 more
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Cancer therapy resistance from a spatial‐omics perspective [PDF]
Clinical and Translational MedicineCancer therapy resistance (CTR) remains a significant challenge in oncology. Traditional methods like imaging, liquid biopsies and conventional omics analyses provide valuable insights, but lack the spatial resolution to fully characterise heterogeneity ...
Yinghao Zhang +6 more
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Application of Spatial Omics in the Cardiovascular System [PDF]
ResearchCardiovascular diseases constitute a marked threat to global health, and the emergence of spatial omics technologies has revolutionized cardiovascular research.
Yuhong Hu +3 more
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Seq-Scope-eXpanded: spatial omics beyond optical resolution [PDF]
Nature CommunicationsSequencing-based spatial transcriptomics (sST) enables transcriptome-wide gene expression mapping but falls short of reaching the optical resolution (200–300 nm) of imaging-based methods.
Angelo Anacleto +23 more
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Integrating Spatial Omics and Deep Learning: Toward Predictive Models of Cardiomyocyte Differentiation Efficiency [PDF]
BioengineeringAdvances in cardiac regenerative medicine increasingly rely on integrating artificial intelligence with spatial multi-omics technologies to decipher intricate cellular dynamics in cardiomyocyte differentiation.
Tumo Kgabeng +3 more
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Science, 2023 Spatial omics has been widely heralded as the new frontier in life sciences. This term encompasses a wide range of techniques that promise to transform many areas of biology and eventually revolutionize pathology by measuring physical tissue structure and molecular characteristics at the same time. Although the field came of age in the past 5 years, it
Bressan, Dario +2 more
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SM-Omics is an automated platform for high-throughput spatial multi-omics [PDF]
Nature Communications, 2022 Abstract The spatial organization of cells and molecules plays a key role in tissue function in homeostasis and disease. Spatial transcriptomics has recently emerged as a key technique to capture and positionally barcode RNAs directly in tissues.
S. Vickovic +6 more
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Enablers and challenges of spatial omics, a melting pot of technologies
Molecular Systems Biology, 2023 Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of publications presenting novel methods for obtaining spatially resolved information for any omics data type on spatial scales ranging from subcellular to organismal. From a
Theodore Alexandrov +2 more
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Interactive visualization of spatial omics neighborhoods
F1000Research, 2022 Dimensionality reduction of spatial omic data can reveal shared, spatially structured patterns of expression across a collection of genomic features. We studied strategies for discovering and interactively visualizing low-dimensional structure in spatial omic data based on the construction of neighborhood features.
Tinghui Xu, Kris Sankaran
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Spatial omics: Navigating to the golden era of cancer research
Clinical and Translational Medicine, 2022 The idea that tumour microenvironment (TME) is organised in a spatial manner will not surprise many cancer biologists; however, systematically capturing spatial architecture of TME is still not possible until recent decade.
Yingcheng Wu +4 more
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