Results 91 to 100 of about 64,018 (290)

Emerging AI approaches for cancer spatial omics

GigaScience
Abstract Technological breakthroughs in spatial omics and artificial intelligence (AI) have the potential to transform the understanding of cancer cells and the tumor microenvironment. Here we review the role of AI in spatial omics, discussing the current state-of-the-art and further needs to decipher cancer biology from large-scale ...
Javad Noorbakhsh, Ali Foroughi pour, Jeffrey Chuang   +2 more
openaire   +3 more sources

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

SANTO: a coarse-to-fine alignment and stitching method for spatial omics

Nature Communications
With the flourishing of spatial omics technologies, alignment and stitching of slices becomes indispensable to decipher a holistic view of 3D molecular profile.
Haoyang Li, Yingxin Lin, Wenjia He, Wenkai Han, Xiaopeng Xu, Chencheng Xu, Elva Gao, Hongyu Zhao, Xin Gao   +8 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Unravelling tumour spatiotemporal heterogeneity using spatial multimodal data

Clinical and Translational Medicine
Analysing the genome, epigenome, transcriptome, proteome, and metabolome within the spatial context of cells has transformed our understanding of tumour spatiotemporal heterogeneity.
Chunman Zuo, Junchao Zhu, Jiawei Zou, Luonan Chen   +3 more
doaj   +1 more source

3D visualization of uterus and ovary: tissue clearing techniques and biomedical applications

Frontiers in Bioengineering and Biotechnology
Recent advancements in tissue clearing and three-dimensional (3D) visualization technologies have enabled subcellular-level examination of entire organs, particularly in complex structures such as the ovary and uterus. Traditional histological approaches
Qiqi Liu, Zhuo Song, Simin Liu, Zirui Dong, Xi Zheng, Tak Yeung Leung, Xiaoyan Chen   +6 more
doaj   +1 more source

Microfluidics for morpholomics and spatial omics applications

Lab on a Chip
Created in BioRender. Menon, N. (2025). https://www.BioRender.com/l48m487.
Nishanth Venugopal Menon, Jeeyeon Lee, Tao Tang, Chwee Teck Lim   +3 more
openaire   +2 more sources

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

Microbiome in cancer metastasis: biological insights and emerging spatial omics methods

Frontiers in Cellular and Infection Microbiology
The role of the microbiome in cancer metastasis has emerged as a critical area of research, with growing evidence suggesting that microbial composition and interactions within the tumour microenvironment may significantly influence metastatic progression.
Marianne Meyers, Charlotte B. A. Stoffels, Gilles Frache, Elisabeth Letellier, Maureen Feucherolles   +4 more
doaj   +1 more source

The burgeoning spatial multi-omics in human gastrointestinal cancers [PDF]

PeerJ
The development and progression of diseases in multicellular organisms unfold within the intricate three-dimensional body environment. Thus, to comprehensively understand the molecular mechanisms governing individual development and disease progression ...
Weizheng Liang, Zhenpeng Zhu, Dandan Xu, Peng Wang, Fei Guo, Haoshan Xiao, Chenyang Hou, Jun Xue, Xuejun Zhi, Rensen Ran   +9 more
doaj   +2 more sources